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CompletedNCT05328570CATUpdated Jun 29, 2025

Comparing the Effects of Exercise on the Structure and Function of Fat Tissue

An interventional study of Oral Glucose Tolerance Test in Adiposity, sponsored by University of Michigan. Completed at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-29.

Sponsored by University of Michigan · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 1 year 10 months after the study started (first participant enrolled Jun 2020, registered Apr 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
45
Allocation
Not applicable
Ages
18 Years to 40 Years
Sex
All
01

Study summary

Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.

02

Conditions studied

  • Adiposity

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03

In context

Obesity

6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.

This study's enrollment of 45 is below the median of 78 across 4,878 interventional studies indexed under Obesity.

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Lead sponsor

University of Michigan is the lead sponsor of 1,475 studies on the registry; 196 are open to participants now.

Of its 162 completed or terminated interventional studies of FDA-regulated products, 128 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age: 18-40 years old
  • Body Mass Index: 23-35 kg/m2
  • Women must have regularly occurring menses and must be premenopausal

Exclusion criteria

Exclusion Criteria:

  • Evidence/history of cardiovascular or metabolic disease
  • Medications known to affect lipid or glucose metabolism, or inflammation
  • Weight instability ≥ ± 6 pounds in the last 6 months
  • Tobacco or e-cigarette users
  • Women must not be pregnant or actively lactating
  • Blood pressure > 140/90 mmHg
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
45 participants (actual)

Study arms

  • Experimental
    Oral Glucose Tolerance Test

    Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.

    Diagnostic Test: Oral Glucose Tolerance Test

Interventions

  • Diagnostic testOral Glucose Tolerance Test

    Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.

06

What researchers measure

Primary outcomes

  1. Blood Glucose Level

    mg/dL

    Time frame: 2 hours at Experimental Trial

  2. Adipose tissue fibrosis

    Pico-sirius Red stain (percent stained)

    Time frame: baseline

07

Study locations

1 site
  • University of Michigan
    Ann Arbor, Michigan 48109, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 29, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05328570
Lead sponsor
University of Michigan
Responsible party
Jeffrey F Horowitz (Professor of Movement Science and Director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology, University of Michigan) — Principal investigator
First posted
Apr 14, 2022
Start date
Jun 4, 2020
Primary completion
Aug 3, 2023
Completion
Dec 9, 2024
Last update
Jun 29, 2025

Study contacts

Jeffrey F Horowitz, PhD
principal investigator · University of Michigan

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.

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