An interventional study of Low-dose esketamine infusion and High-dose esketamine infusion in Esketamine and the Quality of Recovery, sponsored by Anqing Municipal Hospital. Completed at 1 site in China. Open to female participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-09.
Sponsored by Anqing Municipal Hospital · Not applicable, Interventional, and Treatment
Some studies have reported that intravenous esketamine reduce postoperative pain intensity. The investigators investigated whether esketamine could improve the the quality of recovery after modified radical mastectomy.
A total of 111 patients were randomly allocated into 3 groups. Patients in group LE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin. Patients in group HE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin. Patients in group CON received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.
Anqing Municipal Hospital is the lead sponsor of 10 studies on the registry; 6 are open to participants now.
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Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin.
Drug: Low-dose esketamine infusion · Drug: High-dose esketamine infusion · Drug: Saline infusion
Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin.
Drug: Low-dose esketamine infusion · Drug: High-dose esketamine infusion · Drug: Saline infusion
Patients received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.
Drug: Low-dose esketamine infusion · Drug: High-dose esketamine infusion · Drug: Saline infusion
Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin.
Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin.
Patients received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.
Quality of recovery scores (QoR-15)
Our primary outcome was quality of recovery scores (QoR-15) 1 day after operation
Time frame: 1 day after operation
Pain visual analogue scale scores
Secondary Outcome Measure was pain visual analogue scale scores
Time frame: The first 48 hours after operation
This study is completed, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.
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Anqing Municipal Hospital