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CompletedNCT05286424LipoTechUpdated Aug 25, 2022

Lipofilling: Optimal Harvesting Techniques for Breast Reconstruction After Mastectomy in Plastic Aesthetic and Reconstructive Surgery

An interventional study of fat grafting in The Impact of Adipose Tissue Quality on Fat Graft Retention, sponsored by Medical University of Graz. Completed at 1 site in Austria. Open to female participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2022-08-25.

Sponsored by Medical University of Graz · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 1 year after the study started (first participant enrolled Feb 2021, registered Mar 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years to 70 Years
Sex
Female
01

Study summary

The primary aim of this project is to standardize the method for lipofilling by identifying the best technique. In this context, the study will investigate the impact of adipose tissue composition and ideal quantity of the injected fat particularly in view of resorption rate. Correlations between adipose tissue composition, amount of transferred fat, already existing subcutaneous fat layer at the grafting site and resorption rate will be made.

The punch biopsy and the non-invasive Lipometer measurements to determine the subcutaneous fat layer thickness in the harvesting and grafting region will be performed in 10 female subjects that undergo elective lipofilling.

The study was registered on Clinicaltrials.gov after start of recruitment.

02

Conditions studied

  • The Impact of Adipose Tissue Quality on Fat Graft Retention

Keywords

  • fat graft, adipose tissue
03

In context

Lead sponsor

Medical University of Graz is the lead sponsor of 459 studies on the registry; 97 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Women, age 18-70 years (limited upwards due to the indication for lipofilling and the amount of possible secondary diseases)
  • History of BRCA1 and BRCA2 - positive breast cancer with following subcutaneous mastectomy
  • Planned, elective breast-lipofilling
  • Thickness of the skin and subcutaneous fat layer of min. 1 cm (detected via sonography)
  • Currently healthy individual, willing to participate in this study

Exclusion criteria

Exclusion Criteria:

  • Previous surgery at the harvesting site (e.g. caesarian section)
  • Pregnancy or planned pregnancy
  • Current or preceded chemotherapy
  • Preceded radiatio
  • Unable to fully understand study procedures and to provide informed consent
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Interventions

  • Procedurefat grafting

    Fat will be removed from abdomen or legs, processed and re-injected into grafting sites.

    Also known as: lipofilling

06

What researchers measure

Primary outcomes

  1. Adipose tissue dependent take rate

    Detect an adipose tissue composition-dependent take rate

    Time frame: 12-24 months

07

Study locations

1 site
  • Medizinische Universität Graz
    Graz, 8036, Austria
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 25, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05286424
Lead sponsor
Medical University of Graz
Collaborators
Joanneum Research Forschungsgesellschaft mbH
Responsible party
Sponsor
First posted
Mar 18, 2022
Start date
Feb 15, 2021
Primary completion
Jul 28, 2021
Completion
Jul 10, 2022
Last update
Aug 25, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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