A Food Effect Study of KC1036 in Healthy Subjects

• 18\~65 years of age, male.
• The weight of male subject ≥50kg, 19≤BMI≤26g/m2.
• Agree to take adequate contraceptive measures to prevent spouse pregnancy during the clinical trail.
• Able to comprehend and willing to sign an informed consent form (ICF).

Exclusion Criteria:

• Diseases such as liver, kidney, endocrine, cardiovascular, respiratory, nervous, mental, digestive tract, lung, immunity, skin, blood or metabolic disorders that are considered clinically significant by investigator, or have a history of these diseases, or have undergone major surgery, or factors that will endanger the safety of the subject or affect the research results.
• Physical examination, vital signs, laboratory examination, 12-ECG and chest film are clinically significant.
• Excessive smoking within 3 months before screening.
• History of drug and food allergy.
• Drinking 14 units of alcohol per week within 6 months prior dosing (1 unit = 360 mL of beer, or 150mL of wine).
• Participate in blood donate blood volume≥200mL or blood loss ≥200mL within 3 month prior dosing.
• Take any prescription, any over-the-counter medication, traditional Chinese medicines, vitamin products within14 days prior dosing.
• Take any clinical trial drugs within 3 months prior dosing.
• Dysphagia or history of gastrointestinal diseases affecting drug absorption.
• Combined with other viral infections (anti-HCV, anti-HIV positive, anti-TP positive, HBsAg positive) or combined with syphilis infection.
• Acute diseases requiring clinical treatment before screening or prior dosing.
• Anyone who refuse to stop ingest foods or drinks containing caffeine, alcohol from 48 hours before dosing to the end of the study.
• Urine drug positive or drug users within 3 months prior dosing.
• The investigator believes that the subjects are not eligible to participate in this trial.