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CompletedNCT05261919Updated Mar 2, 2022

Relationship Between Acupuncture Needling Direction and Electric Current

An interventional study of Acupuncture manipulation in Acupuncture and Electricity; Effects, sponsored by Chang Gung Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-02.

Sponsored by Chang Gung Memorial Hospital · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 2 years 1 month after the study started (first participant enrolled Jan 2020, registered Feb 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Not applicable
Ages
20 Years and older
Sex
All
01

Study summary

This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation.

Read the detailed description

Acupuncture manipulation with needling direction is important for the therapeutic effect based on traditional Chinese medicine theory. However, research usually focuses on the therapeutic effects on the acupoints and acupuncture time rather than on the manipulation method. This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation.

30 healthy participants were recruited in the study. This study employed an Agilent B1500A semiconductor analyzer to investigate the electric characteristics of meridians under directional supplementation and draining manipulation. We measured the electric current of meridians under different manipulation, and compared the difference between supplementation and draining manipulation in healthy individuals.

02

Conditions studied

  • Acupuncture
  • Electricity; Effects

Keywords

  • Acupuncture
  • Directional manipulation
  • Electricity
  • Meridian theory
  • Traditional Chinese medicine
  • Supplementation
  • Draining
03

In context

Lead sponsor

Chang Gung Memorial Hospital is the lead sponsor of 1,064 studies on the registry; 235 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • at least 20 years old
  • agree to the informed consent

Exclusion criteria

Exclusion Criteria:

  • under 20 years old
  • pregnant or breast-feeding women
  • those with an empty stomach before the study
  • a tendency toward bleeding with thrombocytopenia or history of platelets \< 20000 or a user of an anti-platelet drug.
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
30 participants (actual)

Study arms

  • Experimental
    acupuncture with manipulation group

    30 participant were recruited in this study. All the participants received acupuncture at the acupoints (HT7、HT3、SI5、SI8、BL57、BL40、KI3、KI10) and were measured by an Agilent B1500A semiconductor analyzer. The investigator perform acupuncture with supplementation manipulation first, followed by a measurement of the electrical characteristics using Agilent B1500A. The investigator remove the acupuncture and then perform acupuncture with draining manipulation, followed by measurements. After one meridian measurements were completed, the investigator removed the needle and proceeded to the next meridian to repeat the same procedure.

    Procedure: Acupuncture manipulation

Interventions

  • ProcedureAcupuncture manipulation

    The investigator used directional supplementation and draining manipulation. The supplementation manipulation is defined as the angle of needle insertion to skin as 45 degrees with the needle tip in the same direction as the meridian. While the draining manipulation is defined as the angle of needle insertion at 45 degrees with the needle tip direction opposite to that of the meridian.

    Also known as: Directional manipulation

06

What researchers measure

Primary outcomes

  1. The electric current

    Agilent B1500A is a device that can measure the electric current after acupuncture manipulation. The investigators measure the electric current after intervention of supplementation manipulation and draining manipulation respectively.

    Time frame: through study completion, an average of 90 minutes

  2. The voltage

    Agilent B1500A is a device that can measure the voltage after acupuncture manipulation. The investigators measure the voltage after intervention of supplementation manipulation and draining manipulation respectively.

    Time frame: through study completion, an average of 90 minutes

07

Study locations

1 site
  • Kaohsiung Chang Gung Memorial Hospital
    Kaohsiung, 833, Taiwan
08

References and documents

Publications

  • Hung YC, Chen WC, Chang TC, Zheng HX, Liu YW, Tan YF, Lin SK, Lu YH, Hu WL, Tsai TM. Meridian study on the response current affected by electrical pulse and acupuncture. Nanoscale Res Lett. 2020 Jul 10;15(1):146. doi: 10.1186/s11671-020-03373-2. PubMed 32651748 ↗
  • Ifrim Chen F, Antochi AD, Barbilian AG. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-418. PubMed 31658313 ↗
  • Zhang WB, Wang GJ, Fuxe K. Classic and Modern Meridian Studies: A Review of Low Hydraulic Resistance Channels along Meridians and Their Relevance for Therapeutic Effects in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2015;2015:410979. doi: 10.1155/2015/410979. Epub 2015 Mar 2. PubMed 25821487 ↗
  • Lin CH, Tan YF, Tseng ST, Chen WC, Kuo CW, Wu CC, Tsai TM, Hu WL, Chang TC, Hung YC. Meridian study on the response current affected by acupuncture needling direction. Medicine (Baltimore). 2022 Sep 2;101(35):e30338. doi: 10.1097/MD.0000000000030338. PubMed 36107585 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 2, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05261919
Lead sponsor
Chang Gung Memorial Hospital
Responsible party
Sponsor
First posted
Mar 2, 2022
Start date
Jan 1, 2020
Primary completion
Mar 10, 2020
Completion
Dec 31, 2020
Last update
Mar 2, 2022

Study contacts

Yu-Chiang Hung, Professor
principal investigator · Chang Gung Memorial Hospital

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.

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