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WithdrawnNCT05254964Updated Mar 7, 2023

Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient

An interventional study of Cognitive rehabilitation in Stroke, sponsored by Samsung Medical Center. Withdrawn at 1 site in Korea, Republic of. Open to participants aged 19 Years to 80 Years. Per ClinicalTrials.gov, last updated 2023-03-07.

Sponsored by Samsung Medical Center · Not applicable, Interventional, and Treatment

Why this study was withdrawn
Patients not recruited.
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Not applicable
Ages
19 Years to 80 Years
Sex
All
01

Study summary

Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.

02

Conditions studied

  • Stroke

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03

In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

Browse Stroke studies →

Lead sponsor

Samsung Medical Center is the lead sponsor of 980 studies on the registry; 146 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 1 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients aged 19 to 80 years
  • Patients with subacute stroke within 2 weeks of onset
  • First-ever stroke
  • Supratentorial stroke
  • Less than 8 SAFE (shoulder abduction, finger extension) points
  • Less than 35 FMA Upper scores
  • MEP (motor evoked potential) negative
  • Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score

Exclusion criteria

Exclusion Criteria:

  • Difficult to communicate due to severe language impairment.
  • Accompanied by an existing serious neurogenic disease
  • Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
  • If there are difficulties in conducting the research
  • Any patients who are judged by the investigator to be difficult to participate in this study
  • Patients with contraindicated MRI scans
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    Intensive cognitive rehabilitation group

    Participants receive intensive cognitive rehabilitation for 20 hours for 4 weeks.

    Procedure: Cognitive rehabilitation

Interventions

  • ProcedureCognitive rehabilitation

    Intensive cognitive rehabilitation by cognitive therapist for 1 hour on every working 20 days (4 weeks) during the subacute stroke phase

06

What researchers measure

Primary outcomes

  1. Strength of connectivity in brain network obtained from MRI neuroimaging data

    Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.

    Time frame: Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks

07

Study locations

1 site
  • Samsung Medical Center
    Seoul, 06351, Korea, Republic of
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 7, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT05254964
Lead sponsor
Samsung Medical Center
Responsible party
Yun-Hee Kim (Principal Investigator, Samsung Medical Center) — Principal investigator
First posted
Feb 24, 2022
Start date
Feb 1, 2022
Primary completion
Feb 28, 2023
Completion
Feb 28, 2023
Last update
Mar 7, 2023

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.

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