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Status unknownNCT05241912Updated Feb 16, 2022

Supernormal Oxygen Delivery for Patients With Severe Burns

An Early Phase 1 interventional study of Dobutamine in Burn Surgery and Dobutamine, sponsored by Guangzhou Red Cross Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2022-02-16.

Sponsored by Guangzhou Red Cross Hospital · Early Phase 1, Interventional, and Prevention

The sponsor has not verified this record recently (last verified Jan 2022), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Early Phase 1
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
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Study summary

This is a randomized double-blinded study to investigate in which the groups are designated as the control group and the goal-directed fluid therapy group to further evaluate significant differences in rate of complications during burn surgery.

Read the detailed description

This is a randomized double-blinded study to investigate the effect of control group and the goal-directed fluid therapy group on complications during surgery of the burn patients. The groups are designated as the control group and the oal-directed fluid therapy group to further evaluate significant differences in complications during the surgery.

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Conditions studied

  • Burn Surgery
  • Dobutamine

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03

In context

Burns

719 studies on the registry are indexed under Burns; 145 are open to participants now.

This study's planned enrollment of 100 is above the median of 40 across 524 interventional studies indexed under Burns.

Browse Burns studies →

Lead sponsor

Guangzhou Red Cross Hospital is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Severe burn patients

Exclusion criteria

Exclusion Criteria:

  • Patients or families refuse to sign consent
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Study design

Phase
Early Phase 1
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
100 participants (estimated)

Study arms

  • No intervention
    Control group

    Intraoperative fluid management: administration of 6-10 ml/kg/hr of crystalloid solution.

  • Experimental
    Goal-directed fluid group

    Intervention: administration of dobutamine 0.01 - 0.04 U/min after induction of anesthesia. Intraoperative fluid management: administration of 2-4 ml/kg/hr of crystalloid solution.

    Drug: Dobutamine

Interventions

  • DrugDobutamine

    administration of dobutamine 0.01 - 0.04 U/min after induction of anesthesia to maintain oxygen delivery

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What researchers measure

Primary outcomes

  1. Complication

    perioperative complications

    Time frame: One week after operation

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Study locations

1 site
  • Guangzhou Red cross hospital
    Guangzhou, Guangdong 510220, China
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 16, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05241912
Lead sponsor
Guangzhou Red Cross Hospital
Responsible party
Liang Bing (Associate senior doctor, Guangzhou Red Cross Hospital) — Principal investigator
First posted
Feb 16, 2022
Start date
Feb 28, 2022 (estimated)
Primary completion
Jun 1, 2023 (estimated)
Completion
Jun 1, 2023 (estimated)
Last update
Feb 16, 2022

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.

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