An observational study in Urologic Diseases, Surgery and Blood Glucose, High, sponsored by University of Kansas Medical Center. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-05-15.
Sponsored by University of Kansas Medical Center · Observational
Urological surgery patients will have their blood glucose measured before, during, and after surgery. Blood glucose will be measured using a continuous glucose monitor (CGM) device. We hypothesize the presence of a hyperglycemic state towards the end of surgery due to increased metabolic demand.
Surgical stress causes acute insulin resistance, increased circulating free-fatty acids, and reduced blood glucose uptake resulting in hyperglycemia. Intraoperative and postoperative glucose levels are typically only monitored in the diabetic or cardiac surgical patient. There is a lack of data on perioperative glucose levels in most prolonged surgeries and thus a barrier in determining the best glycemic management strategy to prevent or resolve acute insulin resistance and hyperglycemia. Obtaining blood glucose by CGM is less invasive and will avert disruption of current surgical pathways and standards of care while also producing reliable glucose measurements.
193 studies on the registry are indexed under Urologic Diseases; 51 are open to participants now.
This study's enrollment of 20 is below the median of 200 across 49 observational studies indexed under Urologic Diseases.
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Of its 38 completed or terminated interventional studies of FDA-regulated products, 24 (63%) have results posted.
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Adults undergoing major urologic surgery at KUMC
Exclusion Criteria:
To determine the perioperative glycemic changes longitudinally in patients undergoing major urologic surgeries.
Interstitial blood glucose levels measured by Continuous Glucose Monitor (CGM) device, in mg/dL
Time frame: Perioperatively up to post-operative day 4
To determine the effect of perioperative insulin levels on glycemic variations in patients undergoing major urologic surgeries.
Serum insulin in uIU/mL will be measured from participant blood samples
Time frame: Perioperatively up to post-operative day 4
To determine the effect of perioperative insulin, C-peptide, and Free-Fatty Acid (FFA)
C-peptide in ng/mL will be measured from participant blood samples
Time frame: Perioperatively up to post-operative day 4
To determine the effect of perioperative insulin, C-peptide, and Free-Fatty Acid (FFA)
FFA in mmol/L will be measured from participant blood samples
Time frame: Perioperatively up to post-operative day 4
To determine gastric emptying time of a carbohydrate drink.
A specialized carbohydrate beverage will be given to a subset of willing participants in order to establish a feasible interval for consumption before surgery
Time frame: at least 2 days before surgery
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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University of Kansas Medical Center