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CompletedNCT05221437MOFICHEUpdated Feb 3, 2022

Management and Outcome of Fever in Children in Europe

An observational study in Antibiotic Prescription, sponsored by Imperial College London. Completed. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2022-02-03.

Sponsored by Imperial College London · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
38,480
Ages
Up to 18 Years
Sex
All
01

Study summary

This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe.

Read the detailed description

This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe. This study will use large departmental datasets to collect information on at least 50,000 febrile episodes . This study will use large-scale, pseudo-anonymized departmental data, and will not involve consented patient recruitment; nor will it use patient samples. Data included in MOFICHE will be based on that collected as part of routine clinical care. Antibiotic prescription, hospitalisation and number/type of investigations, re-attendance at ED within 5 days of the first hospital presentation will be recorded.

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Conditions studied

  • Antibiotic Prescription
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In context

Lead sponsor

Imperial College London is the lead sponsor of 824 studies on the registry; 178 are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 6 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Febrile children aged 0- 18 years visiting the emergency care.

Inclusion criteria

  • aged 0- 18 years visiting the emergency care.
  • fever measured at ED or history of (measured) fever less than 3 consecutive days prior to presentation at emergency department

Exclusion criteria

Exclusion Criteria:

-

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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
38,480 participants (actual)
Patient registry
No

Interventions

  • Otherantibiotic prescription
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What researchers measure

Primary outcomes

  1. Antibiotic prescription

    number of antibiotic prescriptions

    Time frame: one year

  2. hospitalization

    number of children requiring admission to hospital

    Time frame: one year

  3. Number of investigations

    number of investigations

    Time frame: one year

  4. Number of children re-attending within 5 days of the first hospital presentation.

    Number of re-attendance

    Time frame: one year

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 3, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05221437
Lead sponsor
Imperial College London
Responsible party
Sponsor
First posted
Feb 3, 2022
Start date
Jan 1, 2017
Primary completion
Apr 1, 2018
Completion
Dec 31, 2021
Last update
Feb 3, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.

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