An observational study in Mitochondrial DNA Mutation and Endoscopy, sponsored by Affiliated Hospital to Academy of Military Medical Sciences. Status unknown at 1 site in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-01.
Sponsored by Affiliated Hospital to Academy of Military Medical Sciences · Observational
Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were found. At the same time, organize industry-university-research-medical inspection joint research, aiming at the advanced layout of new structural and functional imaging technologies, combined with some new imaging technologies, such as holography, fluorescence, etc., to explore and develop a new composite endoscopic imaging technology that is advanced, original and suitable for China's national conditions, in order to develop a prototype of multimodal structural and functional imaging digestive endoscope without contrast agent.
In this study, on the basis of previous work, aiming at the visualization of key molecular functions of gastric cancer, a full-chain digestive endoscopic diagnosis system was constructed by using cross-scale medical imaging technology. Mitochondrial DNA mutations in normal gastric tissue, early gastric cancer and advanced gastric cancer were identified by single cell sequencing, and the origin of gastric stem cells was traced and new molecular markers were found. The tissue characteristics are analyzed by the full spectrum imaging device, and the location, distribution and aggregation of key molecules on the cell membrane are observed by the high resolution imaging device, so as to develop an imaging probe with high labeling efficiency and biosafety, and to explore its clinical application to realize the information fusion of structural and functional imaging in the evolution and diagnosis and treatment of gastrointestinal tumors. The structural heterogeneity and molecular heterogeneity of gastrointestinal tumors are clarified from the macro-micro levels, and the full-scale imaging system with the most comprehensive visualization and resolution ability is established from multi-information dimensions and multi-imaging scales.
Affiliated Hospital to Academy of Military Medical Sciences is the lead sponsor of 65 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
People diagnosed or suspected of one of the following common digestive mucosal diseases: gastritis, gastric cancer, colorectal polyps, colorectal cancer
Exclusion Criteria:
Study on the genomic and molecular pathological characteristics of gastrointestinal mucosal lesions
Other: Patients diagnosed as gastrointestinal mucosal lesions
Study on the genomic and molecular pathological characteristics of normal gastrointestinal mucosa
Patients diagnosed as gastritis, gastric cancer, intestinal polyps and colorectal cancer
Single cell sequencing and identification of mitochondrial DNA variation in gastrointestinal lesions
Single cell sequencing and identification of mitochondrial DNA mutations in gastrointestinal lesions were carried out to trace the clonal origin of cells and look for molecular markers
Time frame: 1 month
To explore the multimodal imaging technique for the diagnosis of gastrointestinal mucosal lesions
The tissue characteristics are analyzed by the full spectrum imaging device, the location, distribution and aggregation of key molecules on the cell membrane are observed by the high resolution imaging device, the imaging probe with high labeling efficiency and biosafety is developed, and the clinical application is discussed. in order to realize the information fusion of structural and functional imaging in the process of gastrointestinal tumor evolution and diagnosis and treatment.
Time frame: 1 month
This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Affiliated Hospital to Academy of Military Medical Sciences