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Status unknownNCT05184647Updated Jan 11, 2022

Total Splenectomy vs Partial Splenectomy in Non-malignant Hemoglobinopathies : Study Comparing the Effectiveness

An observational study in Splenectomy; Status, sponsored by University Hospital, Montpellier. Status unknown at 1 site in France. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2022-01-11.

Sponsored by University Hospital, Montpellier · Observational

The sponsor has not verified this record recently (last verified Dec 2021), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Other
Time perspective
Retrospective
Enrollment
100
Ages
Up to 18 Years
Sex
All
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Study summary

Partial splenectomy or total splenectomy are the two surgical treatment of non-malignant hemoglobinoptahie. The aim of this treatment is to decrease transfusion. The main risk is infectious in total splenectomy, that's why partial splenectomy was suggest. But the efficiency of partial splenectomy decrease over time and a totalisation could be mandatory.

02

Conditions studied

  • Splenectomy; Status

Keywords

  • Pediatrics
  • Non-malignant hemoglobinopathies
  • Comprative effectivness
  • Partial Splenectomy
  • Total Splenectomy
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In context

Lead sponsor

University Hospital, Montpellier is the lead sponsor of 1,261 studies on the registry; 226 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Children under 18 years olds with partial or total splenectomy for non malignant hemoglobinopathies

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Children between 0- 18 years olds
  • Total or partial splenectomy
  • Non malignant hémoglobinopathies

Exclusion criteria

Exclusion criteria:

- Total or partial splenectomy outside of non malignant hemoglobinopathies

05

Study design

Observational model
Other
Time perspective
Retrospective
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • Children under 18 years olds with total splenectomy for non Malignant hemoglobinopathie

    Children under 18 years olds with total splenectomy for non Malignant hemoglobinopathie

  • Children under 18 years olds with partial splenectomy for non Malignant hemoglobinopathie

    Children under 18 years olds with partial splenectomy for non Malignant hemoglobinopathie

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What researchers measure

Primary outcomes

  1. Compared the effectiveness with the number of transfusion

    Compared the effectiveness with the number of transfusion after the surgery between total and partial Febrile urinary tract infection was defined as a positive urine examination with a single bacteria with more than 10.5 cfu/mL and more than 10.4 leukocytes/ml associated with fever above 38.5°C and C-reactive protein (CRP) above 50 mg/

    Time frame: Day 1

Secondary outcomes

  1. Number of infectious event in total and partial splenectomy

    Number of infectious event in total and partial splenectomy

    Time frame: Day 1

  2. number of totalisation in partial

    number of totalisation in partial

    Time frame: Day 1

07

Study locations

1 site
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References and documents

Individual participant data

Plan to share: Undecided — NC

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 11, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05184647
Responsible party
Sponsor
First posted
Jan 11, 2022
Start date
Jan 16, 2022 (estimated)
Primary completion
Jun 30, 2022 (estimated)
Completion
Dec 30, 2022 (estimated)
Last update
Jan 11, 2022

Study contacts

Nicolas KALFA, MD
Contact
n-kalfa@chu-montpellier.fr
00334 67 33 87 84
Benoit Tessier, Student
Contact
benoitessier@gmail.com
4 67 33 87 84 ext. 33
Nicolas KALFA
study director · University Hospital, Montpellier

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.

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