An interventional study of Intravenous infusion and Intravenous infusion in Pancreatectomy; Hyperglycemia, sponsored by University Hospital, Gentofte, Copenhagen. Completed at 1 site in Denmark. Open to participants aged 30 Years to 70 Years. Per ClinicalTrials.gov, last updated 2023-03-29.
Sponsored by University Hospital, Gentofte, Copenhagen · Not applicable, Interventional, and Basic science
The two gut-derived hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) is secreted from intestinal cells in relation to a meal and increase insulin secretion from the pancreas. The hormones also exert effects outside the pancreas, but especially for GIP, these are poorly investigated. Because of this, only GLP-1 based drugs (GLP-1 receptor agonists) are on the market for the treatment of type 2 diabetes and obesity. Nonetheless, a new drug is in clinical development: a combined GIP-GLP-1-receptor agonist (tirzepatide), which has shown better results than GLP-1 alone. The mechanism behind these impressive effects are unknown and in this study, the investigators will look into the exptrapancreatic effects of GIP and GLP-1, separate and combined and thus elucidate the mechanisms of action of this new drug class.
699 studies on the registry are indexed under Hyperglycemia; 105 are open to participants now.
This study's enrollment of 13 is below the median of 46 across 521 interventional studies indexed under Hyperglycemia.
Browse Hyperglycemia studies →University Hospital, Gentofte, Copenhagen is the lead sponsor of 154 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: Intravenous infusion
Other: Intravenous infusion
Other: Intravenous infusion
Other: Intravenous infusion
GIP receptor antagonist (GIP(3-30)NH2)
GLP-1 receptor antagonist (exendin(9-39)NH2)
GIP(3-30)NH2 and exendin(9-39)NH2
Saline
Changes in plasma levels of glucose between interventions assessed through frequently blood sampling during the experimental days
mmol/l
Time frame: Up to two months
Changes in plasma levels of glucagon (gut-derived) between interventions assessed through frequently blood sampling during the experimental days
pmol/l
Time frame: Up to two months
Changes in plasma levels of insulin/C-peptide between interventions assessed through frequently blood sampling during the experimental days
pmol/l
Time frame: Up to two months
Changes in plasma triglycerides between interventions assessed through frequently blood sampling during the experimental days.
mmol/l lipoproteins, neutral and complex lipids.
Time frame: Up to two months
Changes in plasma lipoproteins between interventions assessed through frequently blood sampling during the experimental days.
mg/dl
Time frame: Up to two months
Changes in brown adipose tissue activity between interventions, assessed by thermographic camera
Time frame: Up to two months
Changes in adiponectin in plasma between interventions, assessed through frequently blood sampling during the experimental days.
μg/mL
Time frame: Up to two months
Changes in CTX between interventions assessed through frequently blood sampling during the experimental days
ng/ml
Time frame: Up to two months
Changes in plasma P1NP between interventions assessed through frequently blood sampling during the experimental days
ng/ml
Time frame: Up to two months
Plan to share: No
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This study is completed, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.
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University Hospital, Gentofte, Copenhagen