An interventional study of beta blocker discontinuation in Heart Failure With Preserved Ejection Fraction, sponsored by UConn Health. Recruiting at 1 site in United States. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-09-29.
Sponsored by UConn Health · Not applicable, Interventional, and Treatment
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.
UConn Health is the lead sponsor of 182 studies on the registry; 18 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 6 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
HFpEF patient who are currently taking beta blockers
Other: beta blocker discontinuation
beta blocker discontinuation
Changes in KCCQ-23 score
Kansa city cardiomyopathy questionnaire (KCCQ-23)- self-administered, 23-item. questionnaire that quantifies physical limitations, symptoms, self-efficacy, social interference and quality of life. Scores are transformed to a range of 0-100, where higher scores reflect better health status.
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
Changes in cardiac mechanics by echocardiography
Echocardiographic E/e' ratio
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
Changes in biomarker
changes from baseline in BNP level (pg/mL) after 4 weeks of beta blocker discontinuation
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
6 minute walk test
The distance (meters) covered over a time of 6 minutes. A greater distance indicates a better exercise capacity.
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
Plan to share: No
No publications or documents are linked to this record.
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