An observational study in Healthy, sponsored by Société des Produits Nestlé (SPN). Completed at 1 site in China. Open to participants aged 0 Days to 6 Months. Per ClinicalTrials.gov, last updated 2025-11-28.
Sponsored by Société des Produits Nestlé (SPN) · Observational
The aim of the study is to establish the longitudinal microbiome and bone trajectories from birth to 3 years, and to evaluate the influence of nutrition on these trajectories.
The main objective of the study is to understand the influence of nutrition and dietary patterns on microbiome and bone trajectories during early life. Specific research objectives are:
Société des Produits Nestlé (SPN) is the lead sponsor of 314 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Group 1: 690 healthy infants and their mother followed from birth to 12 months Group 2: 690 healthy infants and their mother followed from 6 months to 3 years of age
Healthy infants who fulfill all the following inclusion criteria will be included:
For group 1, healthy infants aged ≤ 10 days after birth (date of birth = Day 0).
For group 2, healthy infants with maximum age of 6 months
Exclusion Criteria:
Group 1: 690 healthy infants and their mother followed from birth to 12 months
Group 2: 690 healthy infants and their mother followed from 6 months to 3 years of age
gut microbiome
microbiome maturation index derived from microbial composition, bacteria function, metabolites
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
dietary factors
derived from infant questionnaires
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
dietary factors
derived from food diaries of the types of complementary feeding, the food consumption, the nutrient intakes, the food source of nutrients, the dietary patterns
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
bone development
bone tibia speed of sounds (SOS) (meter / second) using ultrasound
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
bone health
Bone tibia length using ruler (cm)
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
dietary intakes and health outcomes
derived from infant questionnaires and their food diaries of the types of complementary feeding, the food consumption, the nutrient intakes, the food source of nutrients, the dietary patterns
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
Gut microbiome
microbiome maturation index derived from microbial composition, bacteria function, metabolites
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
Urinary markers of bone metabolism
urinary resorption biomarkers which are Pyridinolin and Deoxypiridinolin Crosslinks by ELISA
Time frame: Group 1: 0-1 year, Group 2: 0.5-3 years
breast milk composition
breast milk composition, macro and micronutrients (e.g. protein, mineral, etc.)
Time frame: Group 1: 0-3 months
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Société des Produits Nestlé (SPN)