An observational study in Myocarditis, Premature Ventricular Contractions and Ventricular Tachycardia (VT), sponsored by Kansas City Heart Rhythm Research Foundation. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-04.
Sponsored by Kansas City Heart Rhythm Research Foundation · Observational
To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.
Hypothesized that occult inflammation is clinically under-recognized in patients with symptomatic PVCs with and without Left ventricular (LV) dysfunction and can be a potential link between the 2 conditions. Aimed to evaluate the incidence of underlying inflammation using the Positron emission tomography (PET) scan in patients presenting with symptomatic PVCs enrolled retrospectively in the MAVERIC registry.
174 studies on the registry are indexed under Myocarditis; 75 are open to participants now.
This study's planned enrollment of 100 is below the median of 208 across 120 observational studies indexed under Myocarditis.
Browse Myocarditis studies →Kansas City Heart Rhythm Research Foundation is the lead sponsor of 29 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Males and females with PVC and ventricular tachycardia (VT) will be enrolled if they meet the inclusion/exclusion criteria
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF
To identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF through laboratory testing, FDG-PET(18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose - positron emission tomography) scan, Cardiac Magnetic Resonance imaging and/or Endomyocardial biopsy.
Time frame: Retrospective Collection between dates January 2014-January 2023
Ascertain whether immunosuppressive therapy (IST) affords short term and long term improvement of LVEF and clinical outcomes
To ascertain whether immunosuppressive therapy (IST) affords short term and long term improvement of LVEF and clinical outcomes in virus negative and FDG-PET positive patients with non-ischemic cardiomyopathy, myocardial inflammation and PVCs.
Time frame: Retrospective Collection between dates January 2014-January 2023
Evaluate whether IST + catheter ablation results in optimal clinical response
To evaluate whether IST + catheter ablation results in optimal clinical response in virus negative and FDG-PET positive patients with PVCs with or without reduced LVEF
Time frame: Retrospective Collection between dates January 2014-January 2023
Start is estimated for Jan 2026; primary completion for Mar 2026, 2 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Kansas City Heart Rhythm Research Foundation