An interventional study of Real transcranial magnetic stimulation (TMS) before conditioning and Real transcranial magnetic stimulation (TMS) before devaluation test in Healthy, sponsored by Northwestern University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-08-19.
Sponsored by Northwestern University · Not applicable, Interventional, and Basic science
This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.
This study will combine functional magnetic resonance imaging (fMRI), non-invasive transcranial magnetic stimulation (TMS), olfactory stimuli, and a devaluation task to define the specific contributions of orbitofrontal cortex (OFC) networks in outcome-guided behavior. We will use network-targeted TMS to modulate activity within anterior OFC and posterior OFC networks, examining if they have different contributions to decision-making. This is a randomized, between-subjects design.
Northwestern University is the lead sponsor of 1,396 studies on the registry; 199 are open to participants now.
Of its 102 completed or terminated interventional studies of FDA-regulated products, 73 (72%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will receive TMS and sham targeting the OFC network.
Device: Real transcranial magnetic stimulation (TMS) before conditioning · Device: Real transcranial magnetic stimulation (TMS) before devaluation test · Device: Sham transcranial magnetic stimulation (TMS)
Participants will receive TMS and sham targeting the posterior OFC network.
Device: Real transcranial magnetic stimulation (TMS) before conditioning · Device: Real transcranial magnetic stimulation (TMS) before devaluation test · Device: Sham transcranial magnetic stimulation (TMS)
Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the conditioning phase of the task.
Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the devaluation test phase of the task.
Sham TMS will be applied using the MagVenture MagPro X100 stimulator with the placebo side of the Cool-B65 A/P coil.
Behavior on devaluation task
Percentage of cues predicting non-devalued vs devalued odors chosen during the devaluation task.
Time frame: 1 hour after intervention
Resting-state functional magnetic resonance imaging
Resting-state activity determined by functional magnetic resonance imaging.
Time frame: 1 hour after intervention
Plan to share: Yes — All data that underlie results in a publication
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Northwestern University