An interventional study of Muscle typology + exercise training and Muscle typology + training frequency in Muscle Fiber Type, Exercise and Training Frequency, sponsored by University Ghent. Completed at 1 site in Belgium. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-12.
Sponsored by University Ghent · Not applicable, Interventional, and Basic science
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.
Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
University Ghent is the lead sponsor of 345 studies on the registry; 85 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.
Other: Muscle typology + exercise training · Other: Muscle typology + training frequency
The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.
Other: Muscle typology + exercise training · Other: Muscle typology + training frequency
Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.
Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.
Change from baseline muscle volume at 9 weeks
Muscle volume of the legs and the upper arms - MRI
Time frame: Pre and post the 9 weeks training period
Change from baseline dynamic muscle strength at 3 weeks
Upper legs and upper arms - strength training devices
Time frame: Pre, mid and post 9 weeks training period
Change from baseline dynamic muscle strength at 6 weeks
Upper legs and upper arms - strength training devices
Time frame: Pre, mid and post 9 weeks training period
Change from baseline dynamic muscle strength at 9 weeks
Upper legs and upper arms - strength training devices
Time frame: Pre, mid and post 9 weeks training period
Change from baseline isometric muscle strength at 9 weeks
Upper legs and upper arms - Biodex
Time frame: Pre and post 9 weeks training period
Change in muscle fiber type specific hypertrophy at 9 weeks
Legs - Biopsy (vastus lateralis)
Time frame: Pre and post 9 weeks training period
Change of baseline antropometry at 9 weeks
Height, weight, skinfolds
Time frame: Pre and post 9 weeks training period
Change of baseline skeletal muscle protein content at 9 weeks
Histochemistry and protein content of markers of relevance for skeletal muscle function
Time frame: Pre and post 9 weeks training period
Change of baseline histochemistry at 9 weeks
Histochemistry of markers of relevance for skeletal muscle function
Time frame: Pre and post 9 weeks training period
Change from basline fatigue feeling over 9 weeks training period
Number of repetitions during every training, questionnaire (VAS-scale) before every training, RPE after every training
Time frame: Assessed every training during the 9 weeks training period
Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks
Fasted blood samples
Time frame: Pre and post 9 weeks training period
Plan to share: No
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This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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University Ghent