An interventional study of Adherence Promotion With Person-centered Technology (APPT) System and Standard Reminder System (Active Control) in Adherence, Treatment, sponsored by Florida State University. Completed at 1 site in United States. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-24.
Sponsored by Florida State University · Not applicable, Interventional, and Basic science
This study will examine whether among older adults an adaptive and personalized reminder system can better support adherence to home-based cognitive training over typical reminder systems.
Many cognitive training interventions are associated with poor adherence, and poor adherence is associated with fewer benefits. Further, poor adherence in cognitive intervention studies can interfere with answering fundamental questions regarding intervention efficacy. This study will compare the effects of non-adaptive and smart adherence support systems. Participants will be asked to engage in frequent home-based cognitive training on a computer tablet. In the smart adherence support condition, participants will receive adaptive and tailored reminders based on dynamic algorithms that deploy reminders in a way that considers participant preferences, days and times of previous successful engagement, the success of previous reminder attempts, and answers to brief questions contained within reminder prompts. Parameter weights for these variables will be adjusted dynamically over a 6-month assessment period to ensure that reminders are deployed when they are most likely to be acted upon. This study will investigate adherence to training sessions, multiple times each week for 6 months, representing a large challenge to adherence. Participants will be randomly assigned to one condition or another, and adherence at home will be monitored. This will be an Individually Randomized Group-Treatment Trial (IRGT).
128 studies on the registry are indexed under Treatment Adherence and Compliance; 64 are open to participants now.
This study's enrollment of 190 is above the median of 86 across 107 interventional studies indexed under Treatment Adherence and Compliance.
Browse Treatment Adherence and Compliance studies →Florida State University is the lead sponsor of 245 studies on the registry; 46 are open to participants now.
Of its 16 completed or terminated interventional studies of FDA-regulated products, 9 (56%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
To promote adherence, participants will receive generic reminders when home-based cognitive training has not been completed. This will be in the form of a text message to participants' smart phone.
Behavioral: Standard Reminder System (Active Control)
To promote adherence, participants will receive reminders when home-based cognitive training has not been completed. This will be in the form of a text message to participants' smart phone. In this condition, participants will receive adaptive and tailored reminders based on dynamic algorithms that deploy reminders in a way that considers participant preferences, days and times of previous successful assessments, the success of previous reminder attempts, and answers to brief questions contained within reminder prompts. Parameter weights for these variables will be adjusted dynamically over a 6-month assessment period to ensure that reminders are deployed when they are most likely to be acted upon.
Behavioral: Adherence Promotion With Person-centered Technology (APPT) System
A personalized and adaptive text message reminder system.
A typical text message reminder system.
Adherence (session number)
Number of sessions over 6 months
Time frame: 6 months
Adherence (session length)
Number of sessions reaching at least 80% of the assigned session duration over 6 months
Time frame: 6 months
Adherence (holidays)
Number of extended gaps in between sessions over 6 months
Time frame: 6 months
Objective Cognition (predictor of adherence)
A composite measure of objective cognitive ability
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Subjective Cognition (predictor of adherence)
A composite measure of subjective cognitive deficit
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Self-Efficacy (predictor of adherence)
A composite measure of self-efficacy (beliefs held about ability to complete tasks)
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Technology Proficiency (predictor of adherence)
A composite measure of proficiency with technology
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Perceived Training Efficacy (predictor of adherence)
A composite measure of belief in the the efficacy of cognitive training
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Personality (predictor of adherence)
Measure of stable traits
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Dementia Worry (predictor of adherence)
A composite measure of anxiety over cognitive decline
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Busyness Scale (predictor of adherence)
Self-reported environmental demands of day-to-day life
Time frame: Assessed at baseline, predicting adherence variables over 6 months
Interview
Interview assessing experience in study
Time frame: 6 months
Plan to share: Yes — Deidentified adherence data (time and date of intervention engagement) and scored individual difference measures (at the level of the individual) will be shared online.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: Data will be made available one year after the publication of the first primary outcome paper or two years after the collection of the final participants' data, whichever come first.
Access criteria: Data will be freely available online.
No publications or documents are linked to this record.
This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Treatment Adherence and Compliance →