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RecruitingNCT05015231FISCLOUpdated Aug 20, 2021

Multiparametric MRI for Assessment of Changes of Renal Hemodynamics After Fistula Closure in Kidney Transplant Patients

An observational study in Kidney Transplantation, sponsored by University of Zurich. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-08-20.

Sponsored by University of Zurich · Observational

From the registry’s dates

  • Started Aug 2021; still recruiting 5 years 2 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
30
Ages
18 Years and older
Sex
All
01

Study summary

Assessment of changes of renal hemodynamics by multiparametric MRI after closure of AVF access.

02

Conditions studied

  • Kidney Transplantation

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03

In context

Fistula

731 studies on the registry are indexed under Fistula; 103 are open to participants now.

This study's planned enrollment of 30 is below the median of 100 across 221 observational studies indexed under Fistula.

Browse Fistula studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Kidney transplant recipients with a functioning graft and a patent hemodialysis fistula

Inclusion criteria

  • Written informed consent
  • Age > 18 years
  • Patients wishing to close the fistula and planned for surgical fistula closure
  • eGFR CKD EPI ≥ 45 ml/min/1.73m2 at one year post transplantation
  • Stable eGFR within the past 6 months
  • Controlled blood pressure

Exclusion criteria

Exclusion Criteria:

  • Kidney Transplantation \< 12 months before fistula closure
  • Proteinuria > 500mg/d
  • Presence of donor specific antibodies
  • Rejection within the past 6 months
  • BK virus replication within the past 3 months
  • Cardiac pacemaker, which is not compatible with MRI
  • Claustrophobia
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
30 participants (estimated)
Patient registry
No

Interventions

  • Diagnostic testEchocardiography and MRI

    Echocardiography and renal MRI before and after fistula closure

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What researchers measure

Primary outcomes

  1. Assessment of changes in renal hemodynamics by multiparametric MRI after closure of AVF access

    Assessing changes in renal perfusion

    Time frame: evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure

  2. Assessment of changes in renal hemodynamics by multiparametric MRI after closure of AVF access

    Assessing changes in renal oxygenation

    Time frame: evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure

Secondary outcomes

  1. Correlation between AVF access flow and changes as assessed during pneumatic fistula compression with changes in renal hemodynamics after fistula closure

    Correlation between AVF access flow and changes as assessed during pneumatic fistula compression with changes in renal hemodynamics after fistula closure

    Time frame: evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure

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Study locations

1 of 1 sites recruiting
  • University Hospital Zurich
    Zurich, 8091, Switzerland
    • Thomas Müller, Professor · Contact · 0041 (0)44 255 11 11
    Recruiting
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 20, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05015231
Lead sponsor
University of Zurich
Responsible party
Sponsor
First posted
Aug 20, 2021
Start date
Aug 1, 2021
Primary completion
Dec 31, 2027 (estimated)
Completion
Dec 31, 2027 (estimated)
Last update
Aug 20, 2021

Study contacts

Thomas Müller, Professor
Contact
thomas.müller@usz.ch
0041 (0)44 255 11 11
Thomas Müller, Professor
principal investigator · University Hospital Zurich, Nephrology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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