Bioequivalence Study of Baricitinib From Barcimiant 4 mg Film Coated Tablets (Horus Pharma, Egypt) and Olumiant 4 mg Film Coated Tablets (Eli Lilly Nederland B.V., The Netherlands)

1. Healthy male or female, age 18 to 55 years, inclusive.
2. Enrolled study participants should have normal liver function tests, blood counts, and lipid profiles at baseline prior to study drug administration.
3. Clearly healthy males or females, as determined by medical history and physical examination.
4. Body weight within 15% of normal range according to the accepted normal values for body mass index (BMI).
5. Medical demographics without evidence of clinically significant deviation from normal medical condition, eg.: no history of heart, liver, kidney, gastrointestinal, nervous system, or metabolic abnormalities.
6. Results of clinical laboratory test are within the normal range or with a deviation that is not considered clinically significant by principal investigator.
7. Females should be on a suitable birth control method.
8. Fully informed subjects that consented to participate in the study.

Exclusion Criteria:

1. Subjects with known allergy to the products tested.
2. Prospective study participants who are tested and confirmed positive for latent tuberculosis before enrolling in a bioequivalence study.
3. Have a current or recent history (less than [\<] 30 days prior to screening and/or \<45 days prior to Day -1 in Period 1) of a clinically significant bacterial, fungal parasitic, viral (not including rhinopharyngitis), or mycobacterial infection
4. Have received live vaccine(s) within 3 months of screening, or intend to during the study.
5. Female subjects who are pregnant or nursing.
6. Exclude subjects at an increased risk for thrombosis.
7. Acute infection within one week preceding first study drug administration.
8. History of drug or alcohol abuse.
9. Subject does not comply with the stated instruction of not taking any prescription or non-prescription drugs within two weeks before first study drug administration and until the end of the study.
10. Subject is on a special diet (for example subject is vegetarian).
11. Subject does not agree not to consume any beverages or foods containing methyl-xanthenes e.g. caffeine (coffee, tea, cola, chocolate etc.) 48 hours prior to the study administration of either study period until donating the last sample in each respective period.
12. Subject does not agree not to consume any beverages or foods containing grapefruit 7 days prior to first study drug administration until the end of the study.
13. Subject has a family history of severe diseases which have direct impact on the study.
14. Participation in a bioequivalence study or in a clinical study within the last 8 weeks before first study drug administration.
15. Subject intends to be hospitalized within 3 months after first study drug administration.
16. Subjects who have donated blood or lost more than 500 mL blood within 3 months prior to the study.