An interventional study of buccotherm mouthwash and placebo mouthwash in Buccal Microbiota, sponsored by Rennes University Hospital. Withdrawn at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-12.
Sponsored by Rennes University Hospital · Not applicable, Interventional, and Treatment
The microbiota of the human body is essential to life, and plays an essential role in the protection and development of various pathological conditions. There is a symbiotic or mutualistic relationship between humans and their microbiota. However, when the microbiota becomes dysbiotic, it is associated with pathological conditions. In the oral cavity, dysbiosis is responsible for caries and periodontal pathologies, but other associations have been demonstrated or are suspected with distant pathologies (rheumatoid arthritis, Alzheimer's disease). Mouthwashes are used therapeutically or daily to maintain oral health. The main studies reporting their effects on the ecology of the oral microbiota are for the most part limited to Pasteurian culture techniques (40% of bacteria are not yet cultivable). The advent of new generations of sequencing allows to overcome this limitation and to explore the complexity of bacterial communities, i.e. the symbiosis or dysbiosis of the entire bacterial ecosystem. The control of the oral microbiota to prevent pathologies requires a better knowledge of the oral microbial ecology and will allow the development of new approaches that consider the process of biofilm formation and the disruption of bacterial communication networks. The effects of daily mouthwash must therefore be studied at the level of the entire bacterial community.
Rennes University Hospital is the lead sponsor of 440 studies on the registry; 51 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
buccotherm mouthwash
Other: buccotherm mouthwash
placebo mouthwash
Other: placebo mouthwash
twice a day for 14 weeks
twice a day for 14 weeks
Commensal species of the oral microbiota
Change from baseline in commensal species at 14 weeks
Time frame: week 14
Alpha and beta diversity of the oral microbiota
Change from baseline in alpha and beta diversity at 14 weeks
Time frame: week 14
Coefficient of dysbiosis/symbiosis of the oral microbiota
Change from baseline in coefficient of dysbiosis/symbiosis at 14 weeks
Time frame: week 14
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Rennes University Hospital