An interventional study of Prism Adaptation Therapy in Perceptual Disorders, Stroke and Biomarker, sponsored by University of Utah. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2025-06-17.
Sponsored by University of Utah · Not applicable, Interventional, and Treatment
Preliminary data will be collected about which individuals with spatial neglect from right hemisphere stroke (aiming vs perceptual neglect) improve with Prism Adaptation Training and if there is a particular pattern of damage in the brain that predicts both the type of neglect experienced and whether neglect is improved following Prism Adaptation Training
For preliminary data, twelve individuals with right hemisphere stroke and spatial neglect will participate. After pretesting for type of neglect and its severity, they will have an MRI with Diffusion Tensor Imaging (DTI). Then they will complete 10 sessions of Prism Adaptation Therapy and complete neglect post-testing. Response to Prism Adaptation Therapy will be assessed by comparing neglect scores pre- and post-training. Traditional lesion mapping, structural and functional lesion disconnectivity analyses, and tract-based spatial statistics of DTI measures will be used to examine whether any patterns of damage/dysfunction are related to a diagnosis of aiming neglect and response to Prism Adaptation Therapy.
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within 1 month of right hemisphere stroke
Exclusion Criteria:
other neurologic, medical that would interfere with ability to complete the testing or training
10 sessions (60 trials each) 1x/day of Prism Adaptation Therapy
Behavioral: Prism Adaptation Therapy
Participants wear goggles with built-in prisms (a 20-diopter lens) that shift the visual scene to the right. While wearing the googles they reach to and cross out 60 lines/circles, requiring them to learn to reach more leftward than the visual targets appear. Participants can only see the end of their movements.
Also known as: PAT
Catherine Bergego Scale
asks the impact of neglect behavior on 20 everyday tasks using a 0-3 rating scale. Higher scores = more neglect impact. Total score is sum of item scores
Time frame: baseline before prism adaptation therapy
Catherine Bergego Scale
asks the impact of neglect behavior on 20 everyday tasks using a 0-3 rating scale. Higher scores = more neglect impact. Total score is sum of item scores
Time frame: post-intervention immediately after prism adaptation therapy
Behavioral Attention Test conventional subtests
traditional neuropsychological subtests (line crossing, letter cancelation, star cancellation, figure and shape copying, line bisection, and representational drawing). Total score is the sum of scores on subtests with highest score being 146. A score of 129 or higher indicates neglect
Time frame: baseline pre-prism adaptation therapy
Behavioral Attention Test conventional subtests
traditional neuropsychological subtests (line crossing, letter cancelation, star cancellation, figure and shape copying, line bisection, and representational drawing). Total score is the sum of scores on subtests with highest score being 146. A score of 129 or higher indicates neglect
Time frame: post-intervention immediately after prism adaptation therapy
Plan to share: Undecided — We may share data with colleagues at Emory University and Washington University as they are engaged in similar research and combining data may allow for greater statistical power.
This study is withdrawn, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.
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University of Utah