An interventional study of Paper - based cognitive training in Alzheimer Disease, sponsored by University of Medicine and Pharmacy at Ho Chi Minh City. Completed at 1 site in Vietnam. Open to participants aged 60 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-01-09.
Sponsored by University of Medicine and Pharmacy at Ho Chi Minh City · Not applicable, Interventional, and Treatment
The purpose of this study is to assess the efficacy of paper-based cognitive training in Vietnamese patients with early Alzheimer's disease
3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.
This study's enrollment of 70 is close to the median of 70 across 2,808 interventional studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →University of Medicine and Pharmacy at Ho Chi Minh City is the lead sponsor of 118 studies on the registry; 39 are open to participants now.
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Exclusion Criteria:
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Patients with Alzheimer's disease in the early stage receive 12 weeks paper based cognitive training and standard care (medication)
Other: Paper - based cognitive training
Patients with Alzheimer's disease in the early stage only receive standard care (medication)
Cognitive training
Also known as: Non pharmacological treatment for AD
Change from baseline in the Mini-Mental State Examination (MMSE)
It is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. The score is between 0-30. Higher score indicating better cognition.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Memory tests
Immediate Recall, Delayed Recall, Delayed Recognition are tests that measure memory function. Higher score indicating better cognition.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Trail Making test scores
Raw score, assessing attention, executive function. TMT is divided into two parts, TMT-A and TMT-B. In the TMT part A, circles with number from 1 to 25 are arranged randomly. Numerical sequence should be connected by patients as quickly as possible, cutoff value \> 180 seconds. In the TMT part B, patients must alternate between numbers and letters, cut off value \> 300 second. Cutoff scores indicate the value above suggest cognitive performance is normal.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Digits Span forward and backward
The longest digits of forward and backward are 8 and 7, respectively. The total scores are twelve for each test. Higher score indicating better cognition.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Verbal fluency test
Semantic memory score will be measured using the Verbal fluency test. The verbal fluency test is a short test of verbal functioning. Participants are given 1 min to produce as many animals as possible within a semantic category (category fluency). The participant's score is the number of animals. Higher score means better cognition.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Clock drawing test
1-6 points, with higher scores indicating worse visuo-spatial function.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the 15-Item Version of the Boston Naming Test
Cognitive test of semantic memory. Object naming to confrontation, which also depends upon intact perceptual and word retrieval ability. Higher scores indicating better cognition.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Instrumental Activities of Daily Living (IADL) score.
Instrumental Activities of Daily Living (IADL) is a questionnaire to assess patient's capacity to live independently.
Time frame: 12 weeks from baseline cognitive assessment
Change from baseline in the Zarit Burden Interview (ZBI) score.
Zarit Burden Interview score is a questionnaire to assess patient's caregiver burden.
Time frame: 12 weeks from baseline cognitive assessment
Percentage of participants completes the full 12-week cognitive training.
Every 4 weeks participants will follow-up at Dementia Center and be able to continue the training if they complete 80% of each level of difficulty workload. Therefore, we aim to calculate the percentage of participants who can completes the full 12-week cognitive training.
Time frame: 12 weeks from baseline cognitive assessment
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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University of Medicine and Pharmacy at Ho Chi Minh City