An interventional study of Peripheral nerve stimulation and Commercial knee brace in Stroke, Chronic Stroke and Gait, Hemiplegic, sponsored by MetroHealth Medical Center. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by MetroHealth Medical Center · Not applicable, Interventional, and Basic science
The purpose of this study is to examine the reflex excitability of the rectus femoris in individuals with and without post-stroke Stiff-Knee gait. We use electrical stimulation of the peripheral nerve innervating the rectus femoris for a well-controlled reflex stimulus. We are investigating whether reflex excitability of the rectus femoris correlates with gait kinematics.
The purpose of this study is to investigate the role of hyperreflexia in post-stroke Stiff-Knee gait function. In one aim,
7,286 studies on the registry are indexed under Stroke; 2,013 are open to participants now.
This study's enrollment of 54 is close to the median of 50 across 5,366 interventional studies indexed under Stroke.
Browse Stroke studies →MetroHealth Medical Center is the lead sponsor of 101 studies on the registry; 19 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 7 (58%) have results posted.
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Exclusion criteria:
Individuals with post-stroke Stiff-Knee gait
Other: Peripheral nerve stimulation
Healthy Individuals
Other: Peripheral nerve stimulation · Device: Commercial knee brace
Electrical stimulation of peripheral nerves to measure resulting gait kinematics and surface muscle activity
Knee brace used to limit knee mobility in healthy individuals to imitate stroke survivors and measure resulting gait kinematics and surface muscle activity.
Surface electromyographic recording of leg muscles during different conditions
Recording electrical activity of leg muscles during walking in response to peripheral nerve stimulation
Time frame: 1 hour
Circumduction measure
Hip abduction joint motion measured with motion capture
Time frame: 1 hour
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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