An interventional study of Transcranial Magnetic Stimulation (TMS) in Autism Spectrum Disorder, sponsored by Yale University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by Yale University · Not applicable, Interventional, and Treatment
This is a randomized interventional study designed to evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in adults with autism spectrum disorder (ASD).
The primary objective of this study is to determine whether rTMS increases the brain response to faces in a population of adults with ASD. This study will assess critical aspects of social cognition using the electroencephalogram (EEG), event-related potentials (ERPS), and eye-tracking (ET) prior to and following a single rTMS session (or Sham) to provide preliminary insight into the potential of rTMS as a tool to modify social brain function in this population.
Participant visits will include a baseline assessment of neuropsychological, cognitive and behavioral function, and a pre and post TMS session with EEG (electroencephalogram) and eye-tracking to measure neural and visual attentional social response. Two study visits will be scheduled for each participant lasting approximately 4-5hrs total.
1,727 studies on the registry are indexed under Autism Spectrum Disorder; 504 are open to participants now.
This study's planned enrollment of 60 is above the median of 52 across 1,371 interventional studies indexed under Autism Spectrum Disorder.
Browse Autism Spectrum Disorder studies →Yale University is the lead sponsor of 1,724 studies on the registry; 298 are open to participants now.
Of its 210 completed or terminated interventional studies of FDA-regulated products, 126 (60%) have results posted.
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Exclusion Criteria:
Participants will receive active TMS during their study visit
Behavioral: Transcranial Magnetic Stimulation (TMS)
Participants will receive sham stimulation during their study visit simulating TMS
Behavioral: Transcranial Magnetic Stimulation (TMS)
Subjects will receive both active and sham TMS in a randomized crossover assignment involving two study sessions
right hemisphere N170 latency
EEG brain response to faces as measured by the N170 component in milliseconds
Time frame: Measures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours
proportion of visual attention to the eye region of the face
visual attention to the eye region of the face as measured by eye tracking in seconds
Time frame: Measures will be recorded during the EEG/ET sessions of participant visits for an expected 1-2 hours
Plan to share: No
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Yale University