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CompletedNCT04819165COVIACSUpdated Mar 26, 2021

Healthcare-associated Infections in Severe COVID-19 During 2020

An observational study in Respiration, Artificial, COVID-19 and Health Care Associated Infection, sponsored by Sanatorio Anchorena San Martin. Completed at 1 site in Argentina. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-03-26.

Sponsored by Sanatorio Anchorena San Martin · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
252
Ages
18 Years and older
Sex
All
01

Study summary

In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2. Consequently, the days of stay in ICU increase Identifying the risk factors associated with the development of this complication and developing measures aimed at its prevention could have a favorable impact on the clinical course of seriously ill patients.

Read the detailed description

The rate of catheter-associated bacteremia is 3.78 / 1000 days central venous catheters in polyvalent ICUs.

Some studies suggest that in the context of this pandemic, infections associated with health care have increased, although there are few data referring to Latin America.

The objective of this study is to analyze the incidence of health care associated infections in adult patients on invasive mechanical ventilation with confirmed COVID-19 diagnosis and negative COVID-19 admitted to the Intensive Care Unit of the Anchorena San Martín Clinic, San Martín, Buenos Aires.

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Conditions studied

  • Respiration, Artificial
  • COVID-19
  • Health Care Associated Infection
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In context

Infections

6,687 studies on the registry are indexed under Infections; 807 are open to participants now.

This study's enrollment of 252 is close to the median of 240 across 2,136 observational studies indexed under Infections.

Browse Infections studies →

Lead sponsor

Sanatorio Anchorena San Martin is the lead sponsor of 8 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients admitted to ICU who required invasive mechanical ventilation during the COVID-19 pandemic from March to December 2020.

Inclusion criteria

  • All patients older than 18 years admitted to the intensive care unit of the Anchorena San Martín Clinic who required invasive mechanical ventilation for more than 24 hours in a period between March 2020 and December 2020 were included in the analysis.

Exclusion criteria

Exclusion Criteria:

  • All patients who presented incomplete data in the follow-up sheets were excluded.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
252 participants (actual)
Patient registry
No

Groups and cohorts

  • COVID-19 patients

    Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with confirmed COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab).

    Other: COVID-19

  • non COVID-19 patients

    Patients with invasive mechanical ventilation admitted to the Intensive Care Unit (UCI) of the Anchorena San Martín Clinic, San Martín, Buenos Aires with negative COVID-19 diagnosis (positive polymerase chain reaction in nasopharyngeal swab).

Interventions

  • OtherCOVID-19

    Impact of covid-19 on infections associated with health care devices.

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What researchers measure

Primary outcomes

  1. Incidence of health care associated infections in each group.

    Time frame: March to December 2020

Secondary outcomes

  1. The most frequent pathogens in this population associated with Incidence of health care associated infections.

    Time frame: March to December 2020

  2. Possible factors associated with Incidence of health care associated infections.

    Time frame: March to December 2020

  3. mortality in UCI

    Time frame: March to December 2020

  4. Days of ICU stay

    Time frame: March to December 2020

  5. Days of mechanical ventilation

    Time frame: March to December 2020

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Study locations

1 site
  • Sanatorio Anchorena de San Martin
    San Martín, Buenos Aires B1650CQU, Argentina
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References and documents

Publications

  • Tufan A, Avanoglu Guler A, Matucci-Cerinic M. COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs. Turk J Med Sci. 2020 Apr 21;50(SI-1):620-632. doi: 10.3906/sag-2004-168. PubMed 32299202 ↗
  • Ripa M, Galli L, Poli A, Oltolini C, Spagnuolo V, Mastrangelo A, Muccini C, Monti G, De Luca G, Landoni G, Dagna L, Clementi M, Rovere Querini P, Ciceri F, Tresoldi M, Lazzarin A, Zangrillo A, Scarpellini P, Castagna A; COVID-BioB study group. Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors. Clin Microbiol Infect. 2021 Mar;27(3):451-457. doi: 10.1016/j.cmi.2020.10.021. Epub 2020 Oct 24. PubMed 33223114 ↗
  • Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. Erratum In: JAMA. 2016 Jul 19;316(3):350. doi: 10.1001/jama.2016.6956. JAMA. 2016 Jul 19;316(3):350. doi: 10.1001/jama.2016.9558. PubMed 26903337 ↗
  • Kalanuria AA, Ziai W, Mirski M. Ventilator-associated pneumonia in the ICU. Crit Care. 2014 Mar 18;18(2):208. doi: 10.1186/cc13775. No abstract available. Erratum In: Crit Care. 2016 Jan 28;20:29. doi: 10.1186/s13054-016-1206-8.. Zai, Wendy [corrected to Ziai, Wendy]. PubMed 25029020 ↗
  • Rouze A, Nseir S. Continuous control of tracheal cuff pressure for the prevention of ventilator-associated pneumonia in critically ill patients: where is the evidence? Curr Opin Crit Care. 2013 Oct;19(5):440-7. doi: 10.1097/MCC.0b013e3283636b71. PubMed 23856895 ↗
  • Duszynska W, Rosenthal VD, Szczesny A, Woznica E, Ulfik K, Ostrowska E, Litwin A, Kubler A. Urinary tract infections in intensive care unit patients - a single-centre, 3-year observational study according to the INICC project. Anaesthesiol Intensive Ther. 2016;48(1):1-6. doi: 10.5603/AIT.2016.0001. PubMed 26966105 ↗
  • Rosenthal VD, Dwivedy A, Calderon ME, Esen S, Hernandez HT, Abouqal R, Medeiros EA, Espinoza TA, Kanj SS, Gikas A, Barnett AG, Graves N; International Nosocomial Infection Control Consortium (INICC) Members. Time-dependent analysis of length of stay and mortality due to urinary tract infections in ten developing countries: INICC findings. J Infect. 2011 Feb;62(2):136-41. doi: 10.1016/j.jinf.2010.12.004. Epub 2010 Dec 17. PubMed 21168440 ↗
  • Rouze A, Martin-Loeches I, Povoa P, Makris D, Artigas A, Bouchereau M, Lambiotte F, Metzelard M, Cuchet P, Boulle Geronimi C, Labruyere M, Tamion F, Nyunga M, Luyt CE, Labreuche J, Pouly O, Bardin J, Saade A, Asfar P, Baudel JL, Beurton A, Garot D, Ioannidou I, Kreitmann L, Llitjos JF, Magira E, Megarbane B, Meguerditchian D, Moglia E, Mekontso-Dessap A, Reignier J, Turpin M, Pierre A, Plantefeve G, Vinsonneau C, Floch PE, Weiss N, Ceccato A, Torres A, Duhamel A, Nseir S; coVAPid study Group. Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study. Intensive Care Med. 2021 Feb;47(2):188-198. doi: 10.1007/s00134-020-06323-9. Epub 2021 Jan 3. Erratum In: Intensive Care Med. 2022 Apr;48(4):514-515. doi: 10.1007/s00134-021-06588-8. PubMed 33388794 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 26, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04819165
Lead sponsor
Sanatorio Anchorena San Martin
Responsible party
Matias Accoce (RT, Sanatorio Anchorena San Martin) — Principal investigator
First posted
Mar 26, 2021
Start date
Mar 1, 2020
Primary completion
Dec 31, 2020
Completion
Jan 31, 2021
Last update
Mar 26, 2021

Study contacts

matias accoce
principal investigator · SAnchorena San Martin

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.

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