An observational study in Liver Transplantation, sponsored by Mansoura University. Completed. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2021-03-24.
Sponsored by Mansoura University · Observational
Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.
Data on the long-term consequences of living liver donation are scarce. This study examined clinical, laboratory, and radiological parameters and long-term health-related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48 to 168 months of postdonation follow-up.
We used the 36-item short-form health survey (short form-36 health survey, version 1 [SF-36]). The scores for the 4 following subscales were higher in nondonors than in donors: physical functioning (P = 0.009), role limitations due to physical health (P = 0.002), energy/fatigue (P \< 0.001), and bodily pain (P \< 0.001). The scores on the 8 subscales of the SF-36 were higher in donors with living recipients than in donors whose recipients died (P \< 0.001). Our results suggest that living donor right hepatectomy is safe and results in a postdonation HRQoL similar to that of nondonors in those donors whose recipients are healthy, while donors whose recipients die have a lower HRQoL that is significantly negatively correlated with the time since recipient death and improves over time.
Mansoura University is the lead sponsor of 1,115 studies on the registry; 184 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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237 living liver donors and 239 matched controls.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
cases already underwent hepatectomy for living-donor liver transplantation.
Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).
healthy persons who attended the preoperative clinic while preparing for donation but were rejected because of an ABO blood group mismatch.
Other: health-related quality of life (HRQoL) (36-item short-form health survey, version 1 [SF-36]).
health-related quality of life (HRQoL) (36-item short-form health survey, version 1 \[SF-36\]).
health-related quality of life (HRQoL)
health-related quality of life (HRQoL) (36-item short-form health survey, version 1 \[SF-36\]).
Time frame: 4 to 16 years of follow up
No study locations are listed for this record.
Plan to share: Undecided — Privacy for liver transplantation unit, mansoura university.
No publications or documents are linked to this record.
Ran from May 2004 to primary completion in May 2014, 120 months.
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This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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