An interventional study of Navigator-delivered Home ePRO in Cancer, sponsored by University of Alabama at Birmingham. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-16.
Sponsored by University of Alabama at Birmingham · Not applicable, Interventional, and Health services research
Evaluate implementation of navigator-delivered Home ePRO for all cancer patients across multiple practice sites and assess the impact of Home ePRO on clinical and utilization outcomes.
Randomized controlled trials demonstrated that weekly electronic home-based PRO symptom monitoring with automated alerts to clinicians (Home ePRO) in cancer patients was associated with reduced healthcare utilization, improved quality of life, and increased overall survival. However, these trials were administered using infrastructure supported by research funding. A knowledge gap remains about optimal implementation strategies for and effectiveness of Home ePROs in real-world settings. To address this gap, we will conduct a large-scale population-based implementation of an evidence-based Home ePRO intervention for all adult cancer patients receiving chemotherapy. The investigators' hypothesis is that the implementation of navigator-delivered Home ePRO will be successful and will improve both patient and health system outcomes.
9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.
This study's enrollment of 3,090 is above the median of 50 across 7,253 interventional studies indexed under Neoplasms.
Browse Neoplasms studies →University of Alabama at Birmingham is the lead sponsor of 1,396 studies on the registry; 284 are open to participants now.
Of its 156 completed or terminated interventional studies of FDA-regulated products, 124 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patient Group:
Exclusion Criteria:
- Second opinion only at participating institution.
Patients from UAB/MCI enrolled
Other: Navigator-delivered Home ePRO
The intervention includes standard of care weekly symptom survey delivery to patients, with alerts generated for symptoms that are sent to clinic nurses to address per standard of care protocol
Service Penetration
% of eligible patients enrolled
Time frame: up to 3 months of starting a treatment for cancer
Proportion of Alerts Closed Within 48 Hours
alerts are measured by abstracting alert data from the ePRO database
Time frame: up to 48 hours
% of Patients Completing ≥1 ePRO Survey
ePRO surveys are abstracted from the electronic patient-reported outcome system
Time frame: up to 6 months
% of Expected ePRO Surveys Completed Per Patient
ePRO surveys are abstracter from the database; the surveys completed are compared to those sent
Time frame: up to 6 months
% of Surveys Completed of Surveys Sent to Patient
ePRO surveys are abstracted from the ePRO database including surveys completed
Time frame: up to 6 months
Symptom Trajectory
abstract from ePRO database the symptom alerts; we will report the proportion alerting for the population over 6 months
Time frame: up to 3 months; up to 6 months
Number of ED Visits
Proportion with patients with an ED visit (abstracted from the electronic medical record)
Time frame: up to 3 months, up to 6 months
Number of Hospitalizations
Proportion of patients hospitalized (abstracted from the EMR)
Time frame: up to 3 months, up to 6 months
Number of ICU Visits
Proportion admitted to the ICU
Time frame: up to 3 months, up to 6 months
Total Cost of Care
total costs sent by UAB to payers (abstracted from billing records)
Time frame: up to 3 months, up to 6 months
| Milestone | Patients Enrolled in ePROs |
|---|---|
| Started | 3090 |
| Completed | 3090 |
| Not completed | 0 |
% of eligible patients enrolled
| Participants | Patient Group |
|---|---|
| Service Penetration | 3090 |
alerts are measured by abstracting alert data from the ePRO database
Results for this outcome have not been posted.
ePRO surveys are abstracted from the electronic patient-reported outcome system
Results for this outcome have not been posted.
ePRO surveys are abstracter from the database; the surveys completed are compared to those sent
Results for this outcome have not been posted.
ePRO surveys are abstracted from the ePRO database including surveys completed
Results for this outcome have not been posted.
abstract from ePRO database the symptom alerts; we will report the proportion alerting for the population over 6 months
Results for this outcome have not been posted.
Proportion with patients with an ED visit (abstracted from the electronic medical record)
Results for this outcome have not been posted.
Proportion of patients hospitalized (abstracted from the EMR)
Results for this outcome have not been posted.
Proportion admitted to the ICU
Results for this outcome have not been posted.
total costs sent by UAB to payers (abstracted from billing records)
Results for this outcome have not been posted.
Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Patient Group | — | — | — |
All patients enrolled in remote symptom monitoring
| Age, Categorical(Participants) | Patient Group |
|---|---|
| <=18 years | 0 |
| Between 18 and 65 years | 1669 |
| >=65 years | 1421 |
| Age, Continuous(years) | Patient Group |
|---|---|
| Mean | 61 ± 13 |
| Sex: Female, Male(Participants) | Patient Group |
|---|---|
| Female | 1990 |
| Male | 1100 |
| Race (NIH/OMB)(Participants) | Patient Group |
|---|---|
| American Indian or Alaska Native | 3 |
| Asian | 45 |
| Native Hawaiian or Other Pacific Islander | 0 |
| Black or African American | 803 |
| White | 2097 |
| More than one race | 30 |
| Unknown or Not Reported | 112 |
| Ethnicity (NIH/OMB)(Participants) | Patient Group |
|---|---|
| Hispanic or Latino | 56 |
| Not Hispanic or Latino | 2239 |
| Unknown or Not Reported | 795 |
| Region of Enrollment(Participants) | Patient Group |
|---|---|
| United States | 3090 |
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Plan to share: Undecided
This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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University of Alabama at Birmingham