An observational study in Matrix Metalloproteinase, sponsored by Institut za Rehabilitaciju Sokobanjska Beograd. Status unknown at 1 site in Serbia. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-03-17.
Sponsored by Institut za Rehabilitaciju Sokobanjska Beograd · Observational
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The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.
This study will be designed as a prospective cohort study involving the collection of peripheral blood samples before and one month after percutaneous biliary drainage for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity). Biochemical analyzes are preceded by the entry of data relevant to the research (demographic, anamnestic, clinical and biochemical).
Institut za Rehabilitaciju Sokobanjska Beograd is the lead sponsor of 6 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with malignant obstructive hyperbilirubinemia admitted to hospital and referred to the interventional radiologist for percutaneous biliary drainage.
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pathological confirmation or imaging data confirming malignant disease causing bile duct obstruction, performance status 0-1
Exclusion Criteria:
terminally ill patients, performance status >2, hepatic decompensation, severe underlying cardiac or renal diseases and coagulation disorders.
Value of serum matrix metalloproteinase activity before and one month after PTBD
Procedure: Percutaneous biliary drainage
Collection of peripheral blood samples before and one month after percutaneous biliary drainage performed for patients with malignant obstructive hyperbilirubinemia for further molecular biochemical analysis (measurement of serum matrix metalloproteinase activity).
Also known as: Matrix Metalloproteinase serum activity measurement
MMP-2 and MMP-9 serum activity
MMP serume activity will be measured by molecular biochemical analysis performed on peripheral blood samples taken before and one month after percutaneous biliary drainage
Time frame: during intervention
Plan to share: No
No publications or documents are linked to this record.
Started Dec 2020 (actual). Primary completion is estimated for Mar 2021, 3 months after the start.
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This study is status unknown, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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Institut za Rehabilitaciju Sokobanjska Beograd