An observational study in COVID-19, sponsored by Sohag University. Completed at 1 site in Egypt. Open to participants aged 19 Years to 70 Years. Per ClinicalTrials.gov, last updated 2021-06-24.
Sponsored by Sohag University · Observational
This study is aiming to find the relation between the severity of COVID-19 in diabetic and obese patients and the high serum levels of matrix metalloproteinase-7 (MMP-7),matrix metalloproteinase-9 (MMP-9), TGF-β and PDGF Macrophage Activation Markers
Acute respiratory distress syndrome (ARDS) commonly occurs in COVID-19 patients who are diabetic and obese, ARDS is characterized by inflammation and pulmonary fibrosis mediated by cytokines and biomarkers released from activated alveolar macrophages, also cytokine storm may occurs leading to multiple organ failure. These sequelae of COVID-19 disease in obese and diabetic patients are attributed to elevated plasma lipopolysaccharide which is the main activator of M1 and M2 macrophages. chronic activation of macrophages leads to production of profibrotic markers as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), matrix metalloproteinase-7 (MMP7) and matrix metalloproteinase-9 (MMP9) which promote fibrogenesis. In this research, we measure circulatory alveolar macrophage activation markers in COVID-19 obese patients with type 1 and type 2 diabetes.
7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's enrollment of 70 is below the median of 261 across 3,136 observational studies indexed under COVID-19.
Browse COVID-19 studies →Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.
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COVID-19 patients admitted to isolation hospital in Sohag "Sohag teaching hospital".
Exclusion Criteria:
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Measurement of matrix metalloproteinase-7 "MMP-7" serum level (pg/ml) as a biomarker of macrophage activation
ELISA "Enzyme linked immunosorbent assay" technique.
Time frame: MMP-7 is measured after admission of patients to isolation hospital along 7 days interval for 21 days, 3 plasma samples are collected on the 7th day of admission, day 14 and day 21
Measurement of matrix metalloproteinase-9 "MMP-9" serum level (pg/L) as a biomarker of macrophage activation
ELISA "Enzyme linked immunosorbent assay" technique.
Time frame: MMP-9 is measured after admission of patients to isolation hospital along 7 days interval for 21 days, 3 plasma samples are collected on the 7th day of admission, day 14 and day 21
Measurement of transforming growth factor B "TGF-B" serum level ( pg/ml) as a biomarker of macrophage activation
ELISA "Enzyme linked immunosorbent assay" technique.
Time frame: TGF-B is measured after admission of patients to isolation hospital along 7 days interval for 21 days, 3 plasma samples are collected on the 7th day of admission, day 14 and day 21
Measurement of platelet derived growth factor "PDGF" serum level (ng/ml) as a biomarker of macrophage activation
ELISA "Enzyme linked immunosorbent assay" technique.
Time frame: PDGF is measured after admission of patients to isolation hospital along 7 days interval for 21 days, 3 plasma samples are collected on the 7th day of admission, day 14 and day 21
Plan to share: Undecided
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This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
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Sohag University