CClinicalTrials.gg
Status unknownNCT04683107Updated Dec 24, 2020

Efficacy of Eccentric Versus Isometric Exercise in Reducing Pain in Runners With Proximal Hamstring Tendinopathy

An interventional study of Eccentric protocol and Isometric protocol in Proximal Hamstring Tendinopathy, Tendinopathy and Eccentric Exercise, sponsored by University of Haifa. Status unknown. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2020-12-24.

Sponsored by University of Haifa · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Dec 2020), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
42
Allocation
Randomized
Ages
40 Years and older
Sex
All
01

Study summary

Tendon injuries are the most common injuries in sports. They are difficult to treat and cause prolonged absence and decreased athlete performance. Proximal hamstring tendinopathy (PHT) is one of them. First described by Puranen and Orava in 1988 as hamstring syndrome. This injury is most common in the active population.

PHT is a chronic degenerative injury that is produced by mechanical overload and repetitive stretch. Risk factors include overuse, poor lumbopelvic stability and relative weakness of the hamstring muscles. The phenomenon manifests itself with deep pain in the ischial tuberosity area and projection to the posterior thigh, pain during prolonged sitting, pain during hip flexion and knee extension and pain that increases or arises during running, especially during the swing phase.

Risk factors are divided into internal (systemic and biomechanical) and external factors. Internal factors associated with systemic characteristics, include advanced age, sex, obesity, genetics, inflammation and autoimmune conditions, diabetes, hyperlipidemia, and drug use. The external factors, which are more modifiable, are those that depend on the patient's external environment and include training errors such as increasing training volume and / or intensity too quickly and insufficient recovery that cause an overload on the tendon.

For PHT two conditions are considered provocative - energy storage, an action that is typical in the late swing phase while running and repetitive movements that cause compressive forces of the tendon on ischial tuberosity. Compressive forces increase as the hip or trunk flex which explains why training errors such as an increase in volume or intensity of the training and non-gradual change in training type, such as hurdle or hills training, are considered to be factors involved in PHT.

PHT treatment options include physiotherapy, shock waves, Platelet rich plasma (PRP) and surgical treatment. Non-surgical treatments for tendinopathy includes gradual loading of the tendon under the supervision of the level of pain. The load on the tendon causes an increase in collagen synthesis and an increase in the stiffness and capacity of the tendon which ultimately helps return the athlete to function and reduces the level of pain.

Although the injury mechanism is common among runners and athletes from various endurance disciplines (medium and long distance runners, triathletes, etc.) the phenomenon and its treatment has not been sufficiently studied within this population.

02

Conditions studied

  • Proximal Hamstring Tendinopathy
  • Tendinopathy
  • Eccentric Exercise
  • Isometric Exercise
  • Hamstring Tendon Injury
03

In context

Tendinopathy

413 studies on the registry are indexed under Tendinopathy; 64 are open to participants now.

This study's planned enrollment of 42 is below the median of 50 across 339 interventional studies indexed under Tendinopathy.

Browse Tendinopathy studies →

Lead sponsor

University of Haifa is the lead sponsor of 101 studies on the registry; 25 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Medium and long distance runners and endurance athletes (triathlon, Iron Man)
  • over the age of 40
  • With tendon pain lasting 3 months or more, at the location of hamstring insertion in Ischial tuberosity, that increases during or after running.

Exclusion criteria

Exclusion Criteria:

  • Hamstring tear (posterior thigh muscle) according to MRI
  • Stress fractures of the ischium bone
  • Radiated pain in the posterior thigh originating in the lumbar spine, hip joint or sacroiliac joint
  • Other pathologies or rupture of the hamstring muscle
  • Exclude people who have received therapeutic intervention in the last month
  • Medication use for PHT
  • Pain located medially or laterally to the Ischial tuberosity
  • Pregnant women
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
42 participants (estimated)

Study arms

  • Experimental
    Eccentric protocol

    Other: Eccentric protocol

  • Experimental
    Isometric protocol

    Other: Isometric protocol

Interventions

  • OtherEccentric protocol

    Participants in this arm will perform progressive eccentric exercise protocol

  • OtherIsometric protocol

    Participants in this arm will perform progressive isometric exercise protocol

06

What researchers measure

Primary outcomes

  1. Victorian Institute of Sport Assessment-Proximal Hamstring Tendons (VISA-H) questionnaire

    VISA-H is a patient reported outcome questionnaire with high psychometric properties for measuring pain, function and sporting activity in patients with PHT

    Time frame: 6 weeks

  2. Isometric and eccentric muscle force

    Time frame: 6 weeks

  3. Running performance

    measuring running time for 1.5 km

    Time frame: 6 weeks

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 24, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04683107
Lead sponsor
University of Haifa
Collaborators
Tel-Aviv Sourasky Medical Center
Responsible party
Sponsor
First posted
Dec 24, 2020
Start date
Jan 2021 (estimated)
Primary completion
Jul 2021 (estimated)
Completion
Sep 2021 (estimated)
Last update
Dec 24, 2020

Study contacts

Doron Schlissel, BPT
Contact
schlissel.doron@gmail.com
972-545491070
Einat Kodesh, PHD
Contact
ekodesh@gmail.com
972-523489854

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.

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