An observational study in Mesenteric Ischemia, sponsored by Universidad del Rosario. Completed at 1 site in Colombia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-12-17.
Sponsored by Universidad del Rosario · Observational
Background: Acute mesenteric ischemia is a vascular emergency with high mortality because of ambiguous symptomatology and a lack of early diagnostic markers. Lactate dehydrogenase has been described as a mortality biomarker and bowel necrosis length too. Nevertheless, the association between them has been mildly studied. Our objective was to evaluate the association between serum lactate admission levels, bowel necrosis extension, and mortality. Additionally, we performed a mortality characterization.
Materials and Methods: A retrospective cross-sectional study was designed. We reviewed patients' clinical records with acute mesenteric ischemia that attended a hospital between 2012 and 2018. We compared serum lactate admission levels with bowel necrosis length and mortality. A receiver operating characteristic curve was performed on the last association. As post hoc analysis, a classification and regression tree on mortality was fitted.
40 studies on the registry are indexed under Mesenteric Ischemia; 14 are open to participants now.
This study's enrollment of 74 is below the median of 154 across 26 observational studies indexed under Mesenteric Ischemia.
Browse Mesenteric Ischemia studies →Universidad del Rosario is the lead sponsor of 7 studies on the registry; 1 is open to participants now.
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Seventy-four cases were identified that met the study's criteria. The patients' average age was 73.5 (SD, 10.7) years, and 44 (60%) were men. The mean body mass index was 25 (SD, 2.9) kg/m2. Fifteen (20%) of the patients presented non-occlusive acute mesenteric ischemia.
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Exclusion Criteria:
All the patients that arrived at the hospital with symptoms of mesenteric ischemia, had a registered lactate dehydrogenase. We compared the value with the patient's outcomes.
Serum Lactate in mmol/l
Time frame: 30 days
Bowel necrosis length in cm
Time frame: 30 days
Percentage of patients that died between 30 postsurgical days, %
Time frame: 30 days
Cut value of lactate levels as a predictor of mortality, in mmol/l
A receiver operating characteristics curve
Time frame: 30 days
Plan to share: No — We don't plan to share de IPD.
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This study is completed, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.
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Universidad del Rosario