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RecruitingNCT04648124VICTOIREUpdated Jan 5, 2026

VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies

An observational study in Vision Functional Brain Networks in Patients With Hereditary Retinal Dystrophies, sponsored by Fondation Ophtalmologique Adolphe de Rothschild. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-05.

Sponsored by Fondation Ophtalmologique Adolphe de Rothschild · Observational

From the registry’s dates

  • Primary completion was expected by Jan 2026, 9 months ago, but the record still lists the study as recruiting.
  • Started Jan 2021; still recruiting 5 years 9 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
18 Years and older
Sex
All
01

Study summary

The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.

02

Conditions studied

  • Vision Functional Brain Networks in Patients With Hereditary Retinal Dystrophies
03

In context

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild is the lead sponsor of 311 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with hereditary retinal dystrophies whether or not to undergo implantation surgery

Inclusion criteria

  • Patient over 18 years old
  • Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique
  • Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months
  • Express consent to participate in the study
  • Affiliate or beneficiary of a social security scheme

Exclusion criteria

Exclusion Criteria:

  • Patient benefiting from a legal protection measure
  • Pregnant or breastfeeding woman
  • Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).
  • Other additional ocular pathology that can significantly affect vision
  • Recent eye surgery less than 3 months old
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patients for whom there is no planned implant surgery

    Device: IRMf-r (séquence resting state)

  • Patients for whom implantation surgery is planned

    Device: IRMf-r (séquence resting state)

  • case

    Device: IRMf-r (séquence resting state)

Interventions

  • DeviceIRMf-r (séquence resting state)

    Functional MRI of functional brain networks

06

What researchers measure

Primary outcomes

  1. Localization and characterization of neural networks

    neuronal networks description using rest and morphological functionnal MRIs

    Time frame: baseline

  2. Evolution of neuronal networks after retinal implantation

    neuronal networks description using rest and morphological functionnal MRIs

    Time frame: baseline

07

Study locations

1 of 1 sites recruiting
  • Fondation Adolphe de Rothschild
    Paris, PARIS 75019, France
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 5, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04648124
Lead sponsor
Fondation Ophtalmologique Adolphe de Rothschild
Responsible party
Sponsor
First posted
Dec 1, 2020
Start date
Jan 4, 2021
Primary completion
Jan 2026 (estimated)
Completion
Jul 2028 (estimated)
Last update
Jan 5, 2026

Study contacts

Amélie YAVCHITZ
Contact
ayavchitz@for.paris
0148036454
Augustin LECLER
principal investigator · Fondation Ophtalmologique A. de Rothschild

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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