An observational study in Covid19, sponsored by Assistance Publique - Hôpitaux de Paris. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-11-20.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
Overweight or obese patients are particularly exposed to severe forms of COVID-19. Few data suggest that adipose tissue infected with SARS-CoV-2 could be involved in the onset of the cytokine storm seen in severe forms of COVID-19. The aim of this study is to determine the pathogenesis of SARS-CoV-2-infection of adipose tissue. In particular the investigators will study how this virus enters the adipocyte and how it modulates metabolism and inflammation in the adipose tissue. From these data, the investigators hope to determine at the adipose tissue level, original therapeutic targets to modulate the effects of SARS-CoV-2 at the systemic level.
7,641 studies on the registry are indexed under COVID-19; 487 are open to participants now.
This study's planned enrollment of 60 is below the median of 261 across 3,136 observational studies indexed under COVID-19.
Browse COVID-19 studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,506 studies on the registry; 1,007 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Obese and thin patients operated on for abdominal vascular surgery.
Exclusion Criteria:
Other: Adipose tissue
Other: Adipose tissue
Adipose tissue sampling
Comparison of the expression of ACE2 and TMPRSS2 in the subcutaneous and visceral adipose tissue of obese patients. Determination of cells expressing ACE2 and TMPRSS2 in whole human adipose tissue.
Analysis of the expression of mRNA and ACE2 and TMPRSS2 proteins in the subcutaneous and visceral adipose tissue of normal weight and obese patients
Time frame: 12 months
Demonstration of entry and replication of SARS-CoV-2 in human adipose tissue
Infection of human adipocytes in lean and obese subjects by SARS-CoV-2
Time frame: 12 months
Consequences of infection with SARS-CoV-2 on the metabolism and inflammatory state of adipose tissue.
Assessment of the expression and secretion of inflammatory cytokines (TNF-α, IL-1 , IL-4 , IL-6 , IL-7 , IL-10 , IL-12 , IL-13 , IL-18 ¸ IL-23, INF-α, INF-β) after infection with SARS-CoV-2 of adipose tissue / adipocytes of thin and obese subjects. Evaluation of SARS-CoV-2 infection on the lipolysis of adipose tissue / adipocytes in thin and obese subjects.
Time frame: 12 months
Consequences of infection with SARS-CoV-2 on the metabolism and inflammatory state of adipose tissue.
Evaluation of SARS-CoV-2 infection on the lipolysis of adipose tissue / adipocytes in thin and obese subjects.
Time frame: 12 months
Effect of SARS-CoV-2 infection of adipose tissue / adipocytes from thin and obese subjects on endoplasmic reticulum (ER) homeostasis.
Study whether infection with SARS-CoV-2 activates the RE stress pathways in adipose tissue
Time frame: 12 months
Target endoplasmic reticulum stress to reduce spread of SARS-CoV-2 from adipose tissue
Use of RE stress inhibitors on adipocytes infected with SARS-CoV-2 and assess their effect on the maturation of the virus in infected cells.
Time frame: 12 months
This study is status unknown, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris