An observational study in Postoperative Pain, Lung Cancer and Video Assisted Thoracoscopic Surgery, sponsored by Jannie Bisgaard Stæhr. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-07-01.
Sponsored by Jannie Bisgaard Stæhr · Observational
To investigate the effect of intercostal blockade with and without adjuvants.
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive routine procedure. It's less invasive than thoracotomy but postoperative pain is still a problem.
At Aalborg University Hospital, intercostal blockades with bupivacaine is used as standard pain treatment for patients undergoing VATS. Adding adjuvants to the blockades may prolong the effect.
The aim of this study is to investigate if intercostal nerve blockade with adjuvants (intravenous (IV) dexamethasone) will result in better pain management.
The primary plan was to evaluate the effect of adding IV dexamethasone and perineural adrenaline, but due to adverse effects, adrenaline was first reduced and later removed from the intervention (amendment protocol N-20200040 approved by the Ethics Committee of Northern Jutland on February 2nd 2021).
7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.
This study's enrollment of 45 is below the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.
Browse Lung Neoplasms studies →Jannie Bisgaard Stæhr is the lead sponsor of 3 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult lung cancer patients scheduled to undergo VATS at Aalborg University Hospital.
° Consecutive adult patients over 18 years of age scheduled to undergo VATS because of verified/suspected lung cancer.
Exclusion Criteria:
Perineural bupivacaine without adjuvants.
Drug: Bupivacain
Perineural bupivacaine with intravenous dexamethasone.
Drug: Dexamethasone
Intravenous dexamethasone 8 mg. Given once at the end of surgery.
Bupivacaine dose according to weight. \<60 kg: Total dose 100mg 60-90kg: Total dose 150mg \>90kg: Total dose 200mg Given once at the end of surgery.
Total equipotent dose of opioids
Sum of equipotent opioid doses during the first 24 hours after surgery
Time frame: 24 hours
Time to first administration of opioids after surgery
In hours and minuts
Time frame: 48 hours
Numerical rating scale score
Pain score reported by the patient after surgery from 0 (no pain) to 10 (worst imaginable pain) in whole numbers.
Time frame: 24 hours
Time for full mobilization
The total time for full mobilization (walk with support)
Time frame: Through study completion, an average of 1 week
Total dose of non-opioid analgesics
Sum of non-opioid doses during the first 24 hours after surgery
Time frame: 24 hours
The need for pain medication at discharge
The need for pain medication at discharge (all forms, type, dose)
Time frame: At discharge from hospital, an average of 1 week
Postoperative complication (Empyema)
Empyema (yes/no) as complication to the surgery described in the patients journal at discharge (epicrisis)
Time frame: At discharge from hospital, an average of 1 week
Postoperative complication (Air leakage)
Air leakage (yes/no) as complication to the surgery described in the patients journal at discharge (epicrisis)
Time frame: At discharge from hospital, an average of 1 week
Postoperative complication (Reoperation)
Reoperation (yes/no) as complication to the surgery described in the patients journal at discharge (epicrisis)
Time frame: At discharge from hospital, an average of 1 week
Postoperative complication (Pneumonia)
Pneumonia (yes/no) as complication to the surgery described in the patients journal at discharge (epicrisis)
Time frame: At discharge from hospital, an average of 1 week
Postoperative complication (Drainage of pleural effusion)
Pleural effusion (yes/no) as complication to the surgery described in the patients journal at discharge (epicrisis)
Time frame: At discharge from hospital, an average of 1 week
Postoperative complication (Oyxgen therapy)
The need for supplemental oxygen therapy and need for mechanical ventilation (yes/no) as complication to the surgery described in the patients journal at discharge (epicrisis)
Time frame: At discharge from hospital, an average of 1 week
This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.