An interventional study of Changes in positive end-expiratory pressure and tidal volume in Respiratory Compliance, sponsored by Seoul National University Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 1 Month to 6 Years. Per ClinicalTrials.gov, last updated 2022-05-05.
Sponsored by Seoul National University Hospital · Not applicable, Interventional, and Other
In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.
Then determine the most appropriate combination of positive end-tidal pressure and tidal volume.
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Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
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Exclusion Criteria:
When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order. 1. Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg 2. Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg 3. Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg 4. Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg
Other: Changes in positive end-expiratory pressure and tidal volume
When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order. Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg
Intratidal compliance profiles in each ventilator settings
The investigators will determine Intratidal compliance profile using the changes in compliance over time --\> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high.
Time frame: During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
Respiratory compliance
ml cmH2O-1
Time frame: During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
Driving pressure
cmH2O
Time frame: During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
Blood pressure
mmHg
Time frame: During general anesthesia (up to about 50 min-1 hr after induction of anesthesia)
Plan to share: Undecided
This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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Seoul National University Hospital