An observational study in Menopause and Oxidative Stress, sponsored by Sisli Hamidiye Etfal Training and Research Hospital. Completed at 1 site in Turkey. Open to female participants aged 30 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-12-02.
Sponsored by Sisli Hamidiye Etfal Training and Research Hospital · Observational
Thiol disulfide levels will be determined using venous blood samples from pre- and postmenopausal women to evaluate oxidative stress in menopause. Furthermore, oxidative stress will be assessed according to age, and years since the start of menopause. Also, whether the presence of menopause related osteoporosis has any association with oxidative stress will be determined.
A total of 77 subjects are divided into two groups: study group (postmenopausal women) and control group premenopausal women). Biometric data such as age, bmi, obstetric anamnesis, history of komorbidities, PAP smear results are recorded. Mammography results, dexa scores of post menopausal women are also obtained. Venous blood samples from all subjects are collected. Thiol disulfide levels will be determined from serum samples. Thiol disulfide levels will first be compared between the study and the control group in order to determine the oxidative stress in menopause. In secondary evaluation years of menopause, age, and dexa scores will be included.
Sisli Hamidiye Etfal Training and Research Hospital is the lead sponsor of 110 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Women within 30-75 years of age were recruited to this study. Premenapusal healthy women who visited the clinic for routine gynecological control were included in the control group. Postmenopausal women older than 45 years of age who entered menopause as a natural process were included in the study group.
A total of 43 subjects were included in the study group and 34 subjects were included in the control group
Women who entered menopause as a natural process Women within the age limits Still menstruating healthy women as control subjects
Exclusion Criteria:
Women who have entered menopause prematurely Women who have entered menopause following a surgery Women with medically induced menopause Women without any autoimmune or chronic inflammatory diseases Women who are taking hormone replacement therapy due to menopausal symptoms Women without any malignant diseases
Women older than 45 years of age and who have not had any menstruation for the past 12 months are considered as having entered menopause. These women are included in this group.
Other: Thiol disulfide level
Healthy women who are still having regular menstruations are included in this group
Other: Thiol disulfide level
Venous blood is collected from all subjects and thiol disulfide levels will be determined from the serum samples obtained from the venous blood.
Evaluating Oxidative Stress in Menopause
Thiol disulfide stress will be evaluated using serum samples from postmenopausal women and comparing these results with samples obtained from premenopausal women.
Time frame: 2 months
Evaluating Oxidative Stress According to Years of Menopause
Thiol disulfide levels will be determined and analysis will be done according to the years of menopause
Time frame: 2 months
Evaluating Oxidative Stress According to Menopause Related Osteoporosis
Thiol disulfide levels will be determined and analysis will be done according to the osteoporosis scores evaluated with dxa
Time frame: 2 months
Plan to share: No
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This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
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Sisli Hamidiye Etfal Training and Research Hospital