An observational study in Cognition and Covid-19, sponsored by National Institute on Drug Dependence, China. Status unknown at 1 site in China. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-11-10.
Sponsored by National Institute on Drug Dependence, China · Observational
This study is carried on in Wuchang Hospital in Wuhan, China. The investigators plan to recruit 80 patients with COVID-19 and 80 matched healthy control. Using the design of case-control study, the study aims to assess the neurocognitive functions such as executive function and attentional bias in recovered patients with COVID-19 under normal and stress conditions, and to analyze the influencing factors of neurocognitive functions, such as mental health conditions, inflammation indicators and cardiopulmonary function.
7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's planned enrollment of 160 is below the median of 261 across 3,136 observational studies indexed under COVID-19.
Browse COVID-19 studies →National Institute on Drug Dependence, China is the lead sponsor of 7 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Recovered COVID-19 patients and uninfected residents in Wuhan
Exclusion Criteria:
Recovered COVID-19 patients in Wuhan
Behavioral: Trier Social Stress Test
Uninfected people in Wuhan
Behavioral: Trier Social Stress Test
8-min oral calculation and 5-min speech
working memory
assessed by the n-back task, including 0-back, 1-back and 2-back
Time frame: 10 minutes
Cognitive flexibility
assessed by the trail-making task
Time frame: 3 minutes
Inhibitory control
assessed by the stroop task
Time frame: 10 minutes
Attention Bias
assessed by the dot-probe task
Time frame: 15 minutes
Serum TNFalpha
Concentration of serum TNFalpha in ng/ml will be assessed by ELISA
Time frame: 1 day
Serum IL-6
Concentration of serum IL-6 in ng/ml will be assessed by ELISA.
Time frame: 1 day
CRP
hypersensitive C-reactive protein(hs-CRP) in mg/L will be assessed by Turbidimetric inhibition immuno assay.
Time frame: 1 day
Depression
assessed by Self-Rating Depression Scale, which is consist of 20 items scoring 1 to 4.
Time frame: 3-5 minutes
Anxiety
assessed by Self-Rating Anxiety Scale, which is consist of 20 items scoring 1 to 4.
Time frame: 3-5 minutes
PTSD
assessed by PTSD Checklist for DSM-5 (PCL-5)
Time frame: 3-5 minutes
Sleep
assessed by Pittsburgh sleep quality index (PSQI)
Time frame: 3-5 minutes
General cognition
assessed by Montreal - Cognitive Assessment (MoCA)
Time frame: 8-10 minutes
Cardiopulmonary function 1
maximal inspiration pressure（MIP), maximal expiration pressure（MEP）
Time frame: 15 minutes
Cardiopulmonary function 2
Assessed by the 6-minutes' walk test
Time frame: 10 minutes
Stress response indicator 1
concentration of saliva cortisol stress, assessed by ELISA
Time frame: Saliva samples will be colleted before stress, 0 minutes and 10 minutes after stress.
Stress response indicator 2
Hear rates
Time frame: Assessed before and 0 minute after stress
Stress response indicator 3
Blood pressure before stress and after stress
Time frame: Assessed before and 0 minute after stress
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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National Institute on Drug Dependence, China