An interventional study of Granulocyte Colony Stimulated Factor and Human Chorionic Gonadotropins in Fertility Disorders, sponsored by Al-Azhar University. Status unknown. Open to female participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2020-10-28.
Sponsored by Al-Azhar University · Not applicable, Interventional, and Treatment
Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.
Two hundred females with history of recurrent implantation failure and undergoing Intracytoplasmic Sprem injection (ICSI) were randomized into two groups; the first group (100 patients) received intrauterine Granulocyte colony stimulating factor (GCSF) and the second group (100) received intrauterine Human Chorionic Gonadotropin (HCG) at ovum pick up day. The clinical pregnancy rate was evaluated as a primary outcome after 14 days and ultrasound imaging of gestational sac was evaluated as a secondary outcome after 6 weeks.
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Granulocyte Colony Stimulated Factor was intrauterine injected once at ovum pick up day
Drug: Granulocyte Colony Stimulated Factor
500 IU Human Chorionic Gonadotropins was injected intrauterine once at ovum pick up day
Drug: Human Chorionic Gonadotropins
GCSF was intrauterine injected once at ovum pick up day
Also known as: GCSF, Neupogen, Granix and Zarxio
500 IU of HCG was injected intrauterine once at ovum pick up day
Also known as: HCG, Novarel, and Pregnyl
clinical pregnancy rate
Clinical pregnancy was evaluated by high HCG levels
Time frame: after 14 days from positive pregnancy test
Gestational sac imaging
ultrasound imaging of Gestational sac after 6 weeks of pregnancy
Time frame: 6 weeks of pregnancy
No study locations are listed for this record.
This study is status unknown, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Al-Azhar University