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CompletedNCT04603677NoCo-CoBioUpdated Mar 21, 2023

Northern Colorado COVID-19 Biobank

An observational study in Covid19, sponsored by Colorado State University. Completed at 4 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-03-21.

Sponsored by Colorado State University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
148
Ages
18 Years and older
Sex
All
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Study summary

The NoCo-CoBio Project is a biobanking effort to store and preserve saliva, nasopharyngeal, stool and blood specimens from SARS-CoV-2 PCR (polymerase chain reaction) positive individuals.

Read the detailed description

The investigators have created a biorepository of stool, saliva, nasopharyngeal swab specimens, peripheral blood mononuclear cells, serum, and plasma from SARS-CoV-2 infected individuals for research purposes. The multifaceted biorepository will be used to establish markers predicting various presentations of COVID-19 (coronavirus disease 2019).

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Conditions studied

  • Covid19

Keywords

  • biobank
  • biorepository
  • SARS-CoV-2 infection
  • COVID-19
  • coronavirus
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In context

COVID-19

7,774 studies on the registry are indexed under COVID-19; 482 are open to participants now.

This study's enrollment of 148 is below the median of 260 across 3,188 observational studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

Colorado State University is the lead sponsor of 116 studies on the registry; 20 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 3 (60%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The investigators aim to enroll individuals who have had a positive SARS-CoV-2 PCR, with a goal of enrolling 100 hospitalized patients with acute SARS-CoV-2 infection, as well as 100 convalescent participants.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Those who have had a positive SARS-CoV-2 PCR test

Exclusion criteria

Exclusion Criteria:

  • under 18 years of age
  • pregnant
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
148 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Acute phase of SARS-CoV-2 infection

    Participants with an acute SARS-CoV-2 infection. Intervention will not be implemented in this study.

  • Convalescent phase of SARS-CoV-2 infection

    Participants with a previous diagnosis of SARS-CoV-2 infection, now in the convalescent phase of disease. Intervention will not be implemented in this study.

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What researchers measure

Primary outcomes

  1. Evaluation of parameters for markers of SARS-CoV-2 infection and predictors for severe disease

    Evaluation of parameters for markers of SARS-CoV-2 infection and predictors for severe disease

    Time frame: 6 months

Secondary outcomes

  1. Evaluation of markers and predictors of post acute sequelae of COVID-19

    Evaluation of markers and predictors of post acute sequelae of COVID-19

    Time frame: 2 years

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Study locations

4 sites
  • Colorado State University
    Fort Collins, Colorado 80523, United States
  • Poudre Valley Hospital, UCHealth
    Fort Collins, Colorado 80523, United States
  • Greeley Hospital, UCHealth
    Greeley, Colorado 80634, United States
  • Medical Center of the Rockies, UCHealth
    Loveland, Colorado 80538, United States
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References and documents

Publications

  • Whitcomb LA, Berry K, LaVergne SM, Natter N, Baxter BA, Rao S, Tipton M, Gritsenko MA, Weitz KK, Gerbasi V, Bramer LM, Piehowski PD, Webb TL, Henao-Tamayo M, Chicco AJ, Dunn J, Dutt TS, Ryan EP. Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19. BMC Infect Dis. 2025 Dec 10;26(1):61. doi: 10.1186/s12879-025-11824-3. PubMed 41372813 ↗
  • Stromberg S, Baxter BA, Dooley G, LaVergne SM, Gallichotte E, Dutt T, Tipton M, Berry K, Haberman J, Natter N, Webb TL, McFann K, Henao-Tamayo M, Ebel G, Rao S, Dunn J, Ryan EP. Relationships between plasma fatty acids in adults with mild, moderate, or severe COVID-19 and the development of post-acute sequelae. Front Nutr. 2022 Sep 14;9:960409. doi: 10.3389/fnut.2022.960409. eCollection 2022. PubMed 36185653 ↗
  • LaVergne SM, Stromberg S, Baxter BA, Webb TL, Dutt TS, Berry K, Tipton M, Haberman J, Massey BR, McFann K, Alnachoukati O, Zier L, Heacock T, Ebel GD, Henao-Tamayo M, Dunn J, Ryan EP. A longitudinal SARS-CoV-2 biorepository for COVID-19 survivors with and without post-acute sequelae. BMC Infect Dis. 2021 Jul 13;21(1):677. doi: 10.1186/s12879-021-06359-2. PubMed 34256735 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 21, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04603677
Collaborators
University of Colorado Health
Responsible party
Elizabeth P Ryan (Associate Professor, Colorado State University) — Principal investigator
First posted
Oct 27, 2020
Start date
Jul 8, 2020
Primary completion
Feb 28, 2023
Completion
Feb 28, 2023
Last update
Mar 21, 2023

Study contacts

Bridget Baxter
study director · Colorado State University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.

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