An interventional study of remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia and control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1 in Benzodiazepine, sponsored by Yangzhou University. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2024-01-16.
Sponsored by Yangzhou University · Not applicable, Interventional, and Prevention
Benzodiazepine sedative hypnotics are commonly used intravenous anesthetics in clinical practice. Remimazolam is a new benzodiazepine with the characteristics of rapid onset, short maintenance and recovery time, no accumulation, metabolism independent of liver and kidney function, and no serious side effects, which has a good prospect for clinical application. Now we will study the effects of remimazolam on EEG and postoperative cognitive function ，in order to further understand the clinical application of remimazolam.
Yangzhou University is the lead sponsor of 40 studies on the registry; 5 are open to participants now.
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Drug: remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia
Drug: control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1
remimazolam group was remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia
control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1
The average intraoperative power spectral density in the frontal alpha band
EEG data were collected at the beginning of the room admission, and the collection was ended at the end of the operation.
Time frame: Preoperatively, During operation，End of operation
Changes in the score of MMSE
The outcome above should be measured the day before surgery and 1,2,3,5,7 days after surgery
Time frame: The outcome above should be measured the day before surgery and 1,2,3,5,7 days after surgery
Changes in IL-6, IL-10, and S100-β levels
The outcome above should be measured the day before surgery and 1，3 days after surgery
Time frame: The outcome above should be measured the day before surgery and 1，3 days after surgery
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Yangzhou University