An observational study in Covid19, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 2 sites in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-12.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
The purpose of this study is to describe post-intensive care syndrome (PICS) of patients surviving to coronavirus disease 2019 (COVID19) and their rehabilitation and recovery process from hospital to home return
The novel coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the COVID-19 emerged in December 2019 and was declared pandemic in March 2020.
Although the majority of reported COVID-19 cases are mild, approximatively 5% of patients require a stay in intensive care unit, with mechanical ventilation.
Post intensive care syndrome (PICS) consists of physical, cognitive and psychological dysfunctions.
Little is known about the rate and clinical presentations of PCIS among patients surviving to COVID-19.
The objective of this study is to describe the clinical manifestations of PCIS in COVID-19 patients, and their rehabilitation process until home return.
7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's enrollment of 85 is below the median of 261 across 3,136 observational studies indexed under COVID-19.
Browse COVID-19 studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients hospitalized in cochin or Corentin-celton hospitals after an intensive care unit stay for a COVID19 infection
Inclusion Criteria - patients with covid19 infection :
Inclusion Criteria - control group :
Exclusion Criteria:
- Inability to give consent
Patients with Covid19 infection
Behavioral: Post-intensive Care unit syndrome
Asymptomatic group
Other: Spatiotemporal measurements of walking
Post-intensive Care unit syndrome after an intensive care unit stay for the COVID19
Spatiotemporal measurements of walking in asymptomatic participants from the general population.
Change on cognitive Impairment: Vigilance (RASS)
Used to measure the agitation or sedation level of a person. Range -5 to +4 - Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Change on cognitive Impairment: Cooperation
Yes/no - Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Change on cognitive Impairment: Communication
Yes/no - Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Change on cognitive Impairment: Agitation
Yes/no - Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Change on cognitive Impairment: Delirium
Yes/no - Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Change on cognitive Impairment : Introduction of neuroleptic
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on cognitive Impairment: temporo-spatial disorientation
Yes/no - Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Change on physical Impairment : dyspnea
Yes/No - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment: Modified Borg scale dyspnea score.
Verbal and numerical scale that asks you to rate the difficulty of your breathing Patients are asked to tick the boxes that reflect their dyspnea perception best range 0-10 lesser is better - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : cough
Yes/No - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : respiratory rate
Number of breaths/per minute. - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : ventilation mode
Tracheotomy/ ambient air / OXYGEN THERAPY Other - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : Peripheral capillary oxygen saturation (SpO2) at rest
measured by pulse oximetry, which provides an indirect measurement of arterial oxygenation (SaO2) based on the differential absorption of light by oxygenated and deoxygenated blood during pulsatile blood flow - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : respiratory rate on activity
respiratory rate breathing rate on activity - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : Peripheral capillary oxygen saturation (SpO2) on activity
measured by pulse oximetry, which provides an indirect measurement of arterial oxygenation (SaO2) based on the differential absorption of light by oxygenated and deoxygenated blood during pulsatile blood flow during activity - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : orthostatic hypotension
Yes/no drop in blood pressure that occurs when moving from a laying down (supine) position to a standing (upright) position. - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : electrocardiogram at rest
electrocardiogram at rest - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical impairment : numeric verbal scales of fatigue
self-evaluation numeric verbal scales of fatigue - Patients group ranges (0-10) lesser is better
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment: numeric verbal scales of pain
self-evaluation numeric verbal scales of pain ranges (0-10) lesser is better
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : stiffness or pain involving joints
Yes/No small joints (wrists, fingers, toes) and large joints (shoulders, elbows, hips, knees, ankles) * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : stability of the trunk in siting
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : autonomy for bed-chair transfers
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment autonomy for walking
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment : sores
Yes/no Localisation * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on Imagery cerebral
date and result if applicable - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment neurologic exam
motor or sensory deficits involving the upper and the lower limbs (yes/no) Anosmia Yes/no taste loss Yes/no * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment Medical Research Council (MRC-SS MRC Sum score)
assess muscle strength from Grade 5 (normal) to Grade 0 (no visible contraction). MRC-SS score was defined as the sum of MRC scores from six muscles in the upper and lower limbs on both sides so that the score ranged from 60 (normal) to 0 (quadriplegic). * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on physical Impairment five times sit to stand test
The score is the amount of time (to the nearest decimal in seconds) it takes a patient to transfer from a seated to a standing position and back to sitting five times without use of arms, Equipment • Standard height chair (43-45 cm, 17-18 inches) with a backrest. If the patient cannot perform five stands to complete the test without use of arms, a score of 0 seconds should be documented. * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on cognitive Impairment The Montreal Cognitive Assessment (MoCA)
Designed as a rapid screening instrument for mild cognitive dysfunction. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstruction skills, conceptual thinking, calculations, and orientation. Range 0 -30 higher is better * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Cognitive Impairment Frontal Assessment Battery (FAB)
Total score is from a maximum of 18, higher scores indicating better performance. * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : sadness
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : anxiety
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment: Insomnia
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : Apathy
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : sideration
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : Despair
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : Culpability
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : Conduit addictive
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : psychiatric or psychologic care
Yes/no - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
assess type of psychiatric treatment
Type - Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : Hospital Anxiety and Depression Scale (HADS)
A 14-item self-report screening scale that was originally developed to indicate the possible presence of anxiety and depressive states It contains two 7-item scales: one for anxiety and one for depression both with a score range of 0-21. * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Change on psychological Impairment : Posttraumatic Stress Disorder Checklist Scale (PCL-S)
20-item questionnaire, corresponding to the Manual of Mental Disorders (DSM-5) symptom criteria for PTSD. * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
assess psychological Impairment
Introduction of antidepressant drugs Type * Patients group
Time frame: Change between 10 days and 1 month and 3 months and 6 months after ICU's discharge
assess psychological Impairment
Introduction of neuroleptic Type * Patients group
Time frame: change between 10 days and 1 month and 3 months and 6 months after ICU's discharge
asses demographics information
Age, sex, formal education, marital status, occupation, place of living, socio-professional category * Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
assess comorbidities
number of comorbidities * Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
assess past and current medications
Precise * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
assess related symptoms nature of COVID-19
duration of COVID-19-related symptoms nature Laboratory-confirmed SARS-CoV-2 infection as determined by PCR, or other commercial or public health assay and/or CT-scan showing typical radiological findings * Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
assess characteristics of ongoing hospitalization
number of characteristics of ongoing hospitalization (invasive ventilation, curare, others treatments ) * Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
assess medical complications in intensive care
Pneumopathy pulmonary embolism others * Patients group
Time frame: Between 10 days and 1 month after ICU's discharge
Descriptive data of the rehabilitation care pathway after stay in intensive care until return home
Number of days to discharge from hospital Service of rehabilitation care hospital at home (HAH) return at home * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Number of new medical qualifying events since last contact
complications * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Social status
professional activity unemployment retirement others * Patients group
Time frame: Between 10 days and 1 month and 3 months and 6 months after ICU's discharge
Activities of Daily Living (ADL) scale
Related to personal care (self-performance) looks at four of these tasks: transfer, bed mobility, toileting and eating. The resident's self- performance and the amount of staff support provided are evaluated for all of these tasks ranges from 0 (independent) to 4 (total dependence) * Patients group
Time frame: 3 months and 6 months after ICU's discharge
Quality of life Medical outcome study short form 12 items (MOS-SF-12 ) questionnaire
Self-reported outcome measure assessing the impact of health on an individual's everyday life Patients fill out a 12-question survey which is then scored by a clinician or researcher. Questionnaire consisting of 12 questions that measure 8 health domains to assess physical and mental health. Physical health-related domains include General Health (GH), Physical Functioning (PF), Role Physical (RP), and Body Pain (BP). Mental health-related scales include Vitality (VT), Social Functioning (SF), Role Emotional (RE), and Mental Health (MH). * Patients group
Time frame: 3 months and 6 months after ICU's discharge
Gait analysis 6-minute walk test (6MWT)
Sub-maximal exercise test used to assess aerobic capacity and endurance. The distance covered over a time of 6 minutes is used as the outcome by which to compare changes in performance capacity. * Patients group
Time frame: 3 months and 6 months after ICU's discharge
Balance and Gait analysis
Inertial Sensors to Assess Gait Quality * Patients group
Time frame: 3 months and 6 months after ICU's discharge
Spatio-temporal parameters of walking
Comparison of spatio-temporal measures of walking in patients with severe Covid 19 infection to those of an age- and sex-matched sample of asymptomatic participants. Both groups
Time frame: Inclusion
Plan to share: Undecided
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Assistance Publique - Hôpitaux de Paris