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WithdrawnNCT04525586Updated Dec 9, 2022

lncRNA-based Nomogram to Assist Childhood Asthma Diagnosis

An observational study in Childhood Asthma, sponsored by Children's Hospital of Fudan University. Withdrawn. Open to participants aged 2 Years to 5 Years. Per ClinicalTrials.gov, last updated 2022-12-09.

Sponsored by Children's Hospital of Fudan University · Observational

Why this study was withdrawn
lack of funding
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
0
Ages
2 Years to 5 Years
Sex
All
01

Study summary

Asthma is the most common chronic disease in children, however, underdiagnosis of childhood asthma is an important issue in asthma management. The lack of reliable and objective diagnostic indicators requires the development of rapid and accurate strategies for the early diagnosis of childhood asthma. Recent studies have found a correlation between long-chain non-coding RNA (lncRNA) expression and childhood asthma, suggesting that lncRNA may be a potential biomarker for asthma diagnosis.

Read the detailed description

The investigators envision exploring the early diagnosis of asthma by combining lncRNA with electronic medical records. In this project, the investigators will combine high-throughput sequencing, asthma case database, electronic medical record and informatics to investigate the feasibility of combining lncRNA with electronic medical record for asthma diagnostic model. The expected results will establish the foundation for the diagnosis and treatment of childhood asthma and open up new ideas.

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Conditions studied

  • Childhood Asthma

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03

In context

Asthma

3,921 studies on the registry are indexed under Asthma; 507 are open to participants now.

Browse Asthma studies →

Lead sponsor

Children's Hospital of Fudan University is the lead sponsor of 262 studies on the registry; 92 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
2 Years to 5 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Children with recurrent wheezing who apply to Department of Respiratory Medicine, Children's Hospital of Fudan University.

Inclusion criteria

children with recurrent wheezing

Exclusion criteria

Exclusion Criteria:

  1. diagnosis of other chronic respiratory disease (e.g. cystic fibrosis, bronchopulmonary dysplasia, etc)
  2. immunodeficiency- acquired or congenital
  3. neuromuscular disease
  4. congenital heart disease
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
0 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • It's just an observational study, no interventions

    children with recurrent wheezing

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What researchers measure

Primary outcomes

  1. rate of early diagnosis of childhood asthma

    a diagnosis of transient wheeze or asthma was made by a pediatric pulmonologist. This classification was based on symptoms, use of asthma medication, and lung function features.

    Time frame: 24 months

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No — The investigators do not currently have an individual participant data sharing plan. However, de-identified research data/documents may be shared in the future with other investigators who share similar research interests. Specimens and data will not be released without (1) PI written permission and (2) appropriate Institutional Review Board (IRB) approval. Data use and/or material transfer agreements will also be required as applicable to outside researchers.

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 9, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04525586
Lead sponsor
Children's Hospital of Fudan University
Responsible party
Sponsor
First posted
Aug 25, 2020
Start date
Dec 31, 2021 (estimated)
Primary completion
Sep 30, 2022 (estimated)
Completion
Sep 30, 2022 (estimated)
Last update
Dec 9, 2022

Study contacts

Liling Qian, PhD.
study director · Children's Hospital of Fudan University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Dec 2022. You cannot join it, but the record below documents what was studied.

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