An interventional study of Oral Oxytocin and Oral Placebo in Healthy, sponsored by University of Electronic Science and Technology of China. Status unknown at 1 site in China. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-30.
Sponsored by University of Electronic Science and Technology of China · Not applicable, Interventional, and Basic science
The main aim of the study is to investigate whether orally administered oxytocin (24IU) could modulate attention control using a social-emotional saccade/antisaccade eye-tracking paradigm.
Numerous studies have reported the effect of intranasally administered oxytocin on attentional processing including stimulus-driven bottom-up processing and top-down goal-directed inhibitory control. However, it is unclear whether the functional effects are mediated by the peptide directly entering the brain or indirectly via raising peripheral concentrations. One possible method of producing a similar pattern of increased peripheral oxytocin concentrations but without the possibility of direct entry into the brain would be to administer the peptide lingually. In the present double-blind, between-subject, placebo-controlled study, 80 healthy male subjects will be recruited and receive either oxytocin (24IU) or placebo control administered orally (lingual). 45 minutes after treatment subjects are required to complete a social-emotional saccade/antisaccade eye-tracking paradigm. This paradigm uses social (happy, sad, angry, fear, and neutral faces) as well as non-social (oval shapes) stimuli to explore social- and emotion-specific effects of orally administered oxytocin.
University of Electronic Science and Technology of China is the lead sponsor of 109 studies on the registry; 35 are open to participants now.
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Oxytocin orally (24 IU)
Drug: Oral Oxytocin
Placebo orally (24 IU, identical ingredients, except the active agent)
Drug: Oral Placebo
Administration of oxytocin orally (24 IU)
Administration of placebo orally (24 IU)
Effect of oral oxytocin administration on saccade/antisaccade latencies towards social (facial) versus non-social (shape) stimuli
Comparison between social-specific saccade/antisaccade latencies (in milliseconds) between the oxytocin and placebo treatment conditions
Time frame: 45 minutes - 100 minutes after treatment
Effect of oral oxytocin administration on error rates of saccade/antisaccade for social (facial) versus non-social (shape) stimuli
Comparison between social-specific error rates of saccade/antisaccade between the oxytocin and placebo treatment conditions.
Time frame: 45 minutes - 100 minutes after treatment
Emotion-specific effects of oral oxytocin administration on saccade/antisaccade latencies towards the separate facial emotions
Comparison between emotion-specific saccade/antisaccade latencies (in milliseconds) between the oxytocin and placebo treatment conditions
Time frame: 45 minutes - 100 minutes after treatment
Emotion-specific effects of oral oxytocin administration on saccade/antisaccade error rates for the separate facial emotions
Comparison between emotion-specific saccade/antisaccade error rates between the oxytocin and placebo treatment conditions
Time frame: 45 minutes - 100 minutes after treatment
Plan to share: No
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This study is status unknown, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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University of Electronic Science and Technology of China