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CompletedNCT04473157Updated Jan 15, 2021

COVID-19 in Patients With Anosmia in Egypt

An observational study in Anosmia, Covid19 and Dysgeusia, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-01-15.

Sponsored by Ain Shams University · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
58
Ages
18 Years and older
Sex
All
01

Study summary

The study aims to test the frequency of severe acute respiratory syndrome new corona virus SARS-CoV-2 or other respiratory viruses in patients presenting with anosmia or dysgeusia to Ain Shams University Hospitals, Cairo, Egypt.

Read the detailed description

Fifty Patients presenting to Triage and/or Ear, Nose and Throat (ENT) clinics in Ain Shams University Hospitals with the chief complaint of Anosmia/ dysgeusia in the period July- September 2020; will undergo thorough history taking, clinical assessment and polymers chain reaction rt-PCR to SARS-COV2; and if proven negative to COVID 19, PCR to other respiratory pathogens will be tested. COVID-19 patients will be managed according to the standard protocol of Ain Shams University Hospitals. Follow up after 3 weeks for the outcome of recovery of the smell sense and seroconversion by rapid test for immunoglobulins IgM/ IgG of COVID 19, for the probability of a false negative PCR at initial visit.

Ethical committee approval for the current study protocol was obtained. Patients will be invited to participate and the informed consent will be signed.

02

Conditions studied

  • Anosmia
  • Covid19
  • Dysgeusia

Keywords

  • Corona virus
  • SARS-CoV-2
  • Olfactory Disturbance
  • Taste Disturbance
03

In context

Anosmia

180 studies on the registry are indexed under Anosmia; 45 are open to participants now.

This study's enrollment of 58 is below the median of 101 across 58 observational studies indexed under Anosmia.

Browse Anosmia studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.

Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Fifty Patients presenting to Triage and/or ENT clinics in Ain Shams University Hospitals with the chief complaint of Anosmia/ dysgeusia in the period July- August 2020

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • adult (>18 years) patients presented with acute-onset anosmia.

Exclusion criteria

Exclusion Criteria:

  • patients with anosmia or gustatory dysfunctions before the epidemic; patients with previous history of chronic sinusitis or previous sinus surgery.
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
58 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna
06

What researchers measure

Primary outcomes

  1. Recovery from Anosmia

    subjective questionnaire about smell and taste

    Time frame: 3 weeks

  2. Seroconversion

    developing IgM/ IgG antibodies by rapid test

    Time frame: 3 weeks

Secondary outcomes

  1. COVID 19

    developing other symptoms of COVID 19

    Time frame: 3 weeks

07

Study locations

1 site
  • Ain Shams University
    Cairo, Egypt
08

References and documents

Publications

  • Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950. doi: 10.1002/alr.22587. Epub 2020 Jun 18. PubMed 32301284 ↗
  • Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C, Boscolo-Rizzo P. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA. 2020 May 26;323(20):2089-2090. doi: 10.1001/jama.2020.6771. PubMed 32320008 ↗
  • Menni C, Valdes AM, Freidin MB, Sudre CH, Nguyen LH, Drew DA, Ganesh S, Varsavsky T, Cardoso MJ, El-Sayed Moustafa JS, Visconti A, Hysi P, Bowyer RCE, Mangino M, Falchi M, Wolf J, Ourselin S, Chan AT, Steves CJ, Spector TD. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med. 2020 Jul;26(7):1037-1040. doi: 10.1038/s41591-020-0916-2. Epub 2020 May 11. PubMed 32393804 ↗
  • Desforges M, Le Coupanec A, Brison E, Meessen-Pinard M, Talbot PJ. Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans. Adv Exp Med Biol. 2014;807:75-96. doi: 10.1007/978-81-322-1777-0_6. PubMed 24619619 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 15, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04473157
Responsible party
Ossama Mansour, MD, FACS (Professor of Otolaryngology, Ain Shams University) — Principal investigator
First posted
Jul 16, 2020
Start date
Jul 1, 2020
Primary completion
Nov 30, 2020
Completion
Dec 30, 2020
Last update
Jan 15, 2021

Study contacts

Ossama I Mansour, MD
principal investigator · Ain Shams University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.

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