An observational study in Hand Eczema, sponsored by University Hospital Bispebjerg and Frederiksberg. Status unknown at 1 site in Denmark. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-04-27.
Sponsored by University Hospital Bispebjerg and Frederiksberg · Observational
This project aims to investigate the prevalence of bacterial colonization and associated factors in health care workers with hand eczema with focus on Staphylococcus aureus.
Two groups will be examined in this study: health care workers with HE and matched controls invited through a questionnaire study which will be sent to approximately 4000 health care workers in Capital Region. Samples from health care workers with and without hand eczema will be collected after obtaining their written informed consent. Collection of samples: Swabs will be rubbed on the skin for 30 seconds on lesional and non-lesional skin on the dominating hand and from the nostrils. The swabs will immediately be stored in -80 C° (research biobank) for subsequent analysis at Statens Serum Institute.
1,084 studies on the registry are indexed under Eczema; 137 are open to participants now.
This study's planned enrollment of 300 is above the median of 100 across 168 observational studies indexed under Eczema.
Browse Eczema studies →University Hospital Bispebjerg and Frederiksberg is the lead sponsor of 68 studies on the registry; 19 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Health care workers from 4 hospitals in Capital Region, Denmark, with and without hand eczema.
Exclusion Criteria:
Swabs will be taken from eczema lesions on dominating hand (if possible) and nostril
Other: eSwabs
swabs will be taken from healthy skin on dominating hand and nostril
Other: eSwabs
from skin
Staphyloccous aureus presence
Prevalence of S. aureus colonization on hands and in nose in two groups of health care workers. The swab samples will be assessed by culturing on selective S. aureus plates (chromID S. aureus; bioMerieux, Marcy l'Etoile, France) and incubated overnight at 37 °C. DNA will be purified from S. aureus isolates using the Qiagen DNeasy Blood and Tissue Purification Kit (Qiagen, Hilden, Germany).
Time frame: Baseline, cross-sectional
CC-types and spa-typing
clonal complex (CC) type and spa-types are characterizing the S. aureus. Will be correlated to departments and professions of health care workers. The S. aureus will be further characterized by spa typing, which will be performed by polymerase chain reaction and Sanger sequencing of the product. The respective CC types will be assigned from the spa type using eBURST (http://eburst.mlst.net).
Time frame: Baseline, cross-sectional
Hand Eczema Severity Index (HECSI)
Validated severity measurement tool for hand eczema performed by the investigator. Severity will be correlated to S. aureus colonization and CC types
Time frame: Baseline, cross-sectional
Plan to share: No
This study is status unknown, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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University Hospital Bispebjerg and Frederiksberg