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CompletedNCT04427878TA/SARS-Cov2Updated Jun 27, 2024

Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?

An interventional study of biopsies of subcutaneous adipose tissue in Covid-19 Patients, sponsored by Centre Hospitalier Universitaire de Nice. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-06-27.

Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
5
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.

02

Conditions studied

  • Covid-19 Patients

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03

In context

COVID-19

7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.

This study's enrollment of 5 is below the median of 100 across 4,099 interventional studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

Centre Hospitalier Universitaire de Nice is the lead sponsor of 709 studies on the registry; 176 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Male or female ≥ 18 years old
  • Patients testing positive for Covid19
  • Patients affiliated to social security
  • Signing of free and informed consent

Exclusion criteria

Exclusion Criteria:

  • Vulnerable persons (- minors,
  • adults under guardianship or curatorship,
  • pregnant women,
  • persons deprived of their liberty,
  • persons who do not master the French language)
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
5 participants (actual)

Study arms

  • Experimental
    patients with Covid-19

    Procedure: biopsies of subcutaneous adipose tissue

Interventions

  • Procedurebiopsies of subcutaneous adipose tissue

    Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue

06

What researchers measure

Primary outcomes

  1. The presence of SARS-CoV2 in adipose tissue of Covid19 patients

    RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection

    Time frame: Day 0

Secondary outcomes

  1. The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    RT-qPCR for IL6

    Time frame: Day 0

  2. The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    RT-qPCR for IL1

    Time frame: Day 0

  3. The expression of inflammatory cytokines in adipose tissue of Covid19 patients

    RT-qPCR for TNFa

    Time frame: Day 0

07

Study locations

1 site
  • CHU de Nice
    Nice, 06000, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 27, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04427878
Lead sponsor
Centre Hospitalier Universitaire de Nice
Responsible party
Sponsor
First posted
Jun 11, 2020
Start date
Aug 3, 2020
Primary completion
Sep 9, 2020
Completion
Sep 9, 2020
Last update
Jun 27, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.

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