An interventional study of Arthroplasty in Infection, sponsored by Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal. Active, not recruiting at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-11.
Sponsored by Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Not applicable, Interventional, and Treatment
The purpose of this study is to compare infection rates when patients, elected for primary or aseptic revision THA / TKA, have a single intravenous antibiotic dose versus one single intravenous antibiotic dose in combination with intra-articular antibiotics. This is a prospective, randomized clinical survey on selected outcome measurements on 1834 subjects who will be recruited in a period of about 2 years.
Group A: patients receiving single dose of IV cefazolin 10-60 minutes before incision.
Group B: patients receiving a single dose of IV cefazolin 10-60 minutes before incision + a single dose of intra-articular vancomycin powder before articulation (hip or knee) closure.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's planned enrollment of 1,832 is above the median of 120 across 4,200 interventional studies indexed under Infections.
Browse Infections studies →Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal is the lead sponsor of 31 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients receiving single dose of IV cefazolin (2 grams if \< 120kg; 3 grams if \>120kg) 10-60 minutes before incision
Procedure: Arthroplasty
Patients receiving a single dose of IV cefazolin (2 grams if \< 120kg; 3 grams if \>120kg) 10-60 minutes before incision + a single dose of intra-articular vancomycin powder (1 gram) before articulation (hip or knee) closure
Procedure: Arthroplasty
All patients include in the study will undergo a lowerlimb arthroplasty, primary or revision
Also known as: Knee arthroplasty, Hip arthroplasty, Knee aseptic revision arthroplasty, Hip arthroplaty revision
Acute Infection rate
Infection rate after after lowerlimb arthroplasty depending on the antibiotic molecule that was given
Time frame: 3 months
Long-term infection rate
Infection rate after after lowerlimb arthroplasty depending on the antibiotic molecule that was given
Time frame: 2 years
Risk factor
Infection rate in patients with risk factors depending on the antibiotic molecule that was given
Time frame: 2 years
Primary vs revision
Infection rate in primary versus revisions surgery depending on the antibiotic molecule that was given
Time frame: 2 years
Surgery time
Infection rate according to surgery time depending on the antibiotic molecule that was given
Time frame: 2 years
The Western Ontario and McMaster Universities Arthritis Index (WOMAC)
Scale from 0 to 97. 97 indicate worse pain, stiffness, and functional limitations
Time frame: baseline, 1 year
EQ-5D-5L
The descriptive system section of the EQ-5D questionnaire produces a 5-digit health state profile that represents the level of reported problems on each of the five dimensions of health
Time frame: baseline, 1 year
This study is active, not recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal