An interventional study of Ejaculated semen sample in COVID-19, Sars-CoV2 and Corona Virus Infection, sponsored by Universitair Ziekenhuis Brussel. Status unknown at 1 site in Belgium. Open to male participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2020-10-28.
Sponsored by Universitair Ziekenhuis Brussel · Not applicable, Interventional, and Diagnostic
The objectives of the study, are to describe detection of SARS-CoV-2 in the semen of COVID-19 positive patients, the duration of positive semen and to investigate the impact on semen quality, thereby providing insights into the early impact on male reproductive function.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a novel coronavirus reported in late December 2019 in Wuhan, China, has spread world-wide with over 1,000,000 coronavirus disease 2019 (COVID-19) cases reported. New developments in molecular virology and immunobiology of SARS-CoV-2, improve our understanding about COVID-19 prevention, management, and possible long-term effects. Although viral transmission occurs predominantly through respiratory droplets, SARS-CoV-2 has been isolated in blood samples and feces from COVID-19 patients, raising questions about viral shedding in other bodily fluids, including semen, as well as alternative modes of transmission.
The objectives are to describe detection of SARS-CoV-2 in the semen of COVID-19 positive patients, the duration of positive semen and to investigate the impact on semen quality, thereby providing insights into the early impact on male reproductive function.
7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's planned enrollment of 20 is below the median of 100 across 4,099 interventional studies indexed under COVID-19.
Browse COVID-19 studies →Universitair Ziekenhuis Brussel is the lead sponsor of 362 studies on the registry; 103 are open to participants now.
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Exclusion Criteria:
Men who are tested positive for SARS-CoV-2 by PCR testing on nasopharyngeal swab.
Diagnostic Test: Ejaculated semen sample
SARS-CoV-2 positive men will be asked to give an ejaculated semen sample, within the seven days after positive testing. Semen samples will be performed every 7 days, until 2 semen PCR tests are negative and will be retested after 3 months.
detection of SARS-CoV-2 in the semen
detection of SARS-CoV-2 in the semen of men positive for SARS-CoV-2 on nasopharyngeal swab
Time frame: within 7 days after positive testing for SARS-CoV-2
duration of SARS-CoV-2 presence in semen
in case of a positive SARS-CoV-2 semen sample, for how long stays the virus present in semen
Time frame: from first positive semen testing until first negative semen testing, upto 15 weeks
semen viscosity
viscosity of semen will be assessed macroscopically
Time frame: from first until last semen analysis, upto 15 weeks
semen volume
semen volume
Time frame: from first until last semen analysis, upto 15 weeks
semen pH
semen pH
Time frame: from first until last semen analysis, upto 15 weeks
Sperm motility
Sperm motility assesment, according to the WHO guidelines of 2010
Time frame: from first until last semen analysis, upto 15 weeks
Sperm morphology
Sperm morphology assesment, according to the WHO guidelines of 2010
Time frame: from first until last semen analysis, upto 15 weeks
Sperm density
Sperm density assesment, according to the WHO guidelines of 2010
Time frame: from first until last semen analysis, upto 15 weeks
Plan to share: No
This study is status unknown, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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Universitair Ziekenhuis Brussel