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CompletedNCT04379297CON-VINCEUpdated Aug 14, 2024

COvid-19 National Survey for Assessing VIral Spread by Nonaffected CarriErs (CON-VINCE)

An observational study in COVID19, sponsored by Luxembourg Institute of Health. Completed at 1 site in Luxembourg. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-08-14.

Sponsored by Luxembourg Institute of Health · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,870
Ages
18 Years and older
Sex
All
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Study summary

CON-VINCE (COvid-19 National survey for assessing VIral spread by Non-affected CarriErs) is a national, monocentric, and longitudinal study aiming to evaluate the spread dynamics of the COVID-19 disease within the Luxembourgish population. Participants who are clinically asymptomatic or present with only mild symptoms will be followed up longitudinally, regularly tested for SARS-CoV-2 by RT-PCR, antibody status, and subjected to an epidemiological, clinical and biological phenotyping to better understand the nature, dynamics of infectivity and spread of the virus in the population. CON-VINCE will also track the psychological and socio-economic impact of long-term containment measures on the general population.

Read the detailed description

To capture the dynamics and impact of the virus spread in the Luxembourgish population, data and sample collection is done every two weeks for two months (4 times in total) with a final follow-up one year after the participant's inclusion in the study. Participants complete questionnaires before each sample collection. The baseline questionnaire captures demographic data, medical history, behavioral and psychological data, and socio-economic status. Participants provided information on medical history, history of allergies, smoking, and chronic medication taken regularly. COVID-19-related data and environmental conditions of the household were obtained.

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Conditions studied

  • COVID19

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Keywords

  • Coronavirus
  • COVID
  • Prevalence
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In context

COVID-19

7,640 studies on the registry are indexed under COVID-19; 488 are open to participants now.

This study's enrollment of 1,870 is above the median of 261 across 3,136 observational studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

Luxembourg Institute of Health is the lead sponsor of 28 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Representative panel of the Luxembourgish population

Inclusion criteria

  • Subjects aged 18 and older of both genders, with a full capacity of consent.
  • SARS-CoV-2-positive individuals with an asymptomatic or oligosymptomatic infection (mild or oligosymptomatic disease course is defined as absence of fever and respiratory distress or cough not attributable to other known chronic disease).
  • OR SARS-CoV-2-negative individuals at the time of inclusion.
  • OR post-infectious SARS-CoV-2-negative individuals with acquired immunity to SARS-CoV-2 and a mild disease course.

Exclusion criteria

Exclusion Criteria:

  • Evolution of the COVID-19 disease requiring a hospital admission before inclusion in the study
  • Presence of fever and respiratory distress/cough at the time of inclusion not attributable to other known chronic disease
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,870 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna
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What researchers measure

Primary outcomes

  1. Prevalence and dynamics of the SARS-COV 2 infection in Luxemburg

    Evaluation of the prevalence by RT-PCR and serology testing

    Time frame: 04.2020-05.2021

  2. Collection of samples for research

    Samples will be analysed and stored for future research

    Time frame: 04.2020-05.2021

Secondary outcomes

  1. Psycho-social evaluation

    Psychological and socio- economic impact of long-term containment measures on the general population

    Time frame: 04.2020-05.2021

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Study locations

1 site
  • Luxembourg Institute of Health
    Strassen, 1445, Luxembourg
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References and documents

Publications

  • Tsurkalenko O, Bulaev D, O'Sullivan MP, Snoeck C, Ghosh S, Kolodkin A, Rommes B, Gawron P, Moreno CV, Gomes CPC, Kaysen A, Ohnmacht J, Schroder VE, Pavelka L, Meyers GR, Pauly L, Pauly C, Hanff AM, Meyrath M, Leist A, Sandt E, Aguayo GA, Perquin M, Gantenbein M, Abdelrahman T, Klucken J, Satagopam V, Hilger C, Turner J, Vaillant M, Fritz JV, Ollert M, Kruger R; CON-VINCE consortium and the ORCHESTRA working group. Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE). BMC Infect Dis. 2024 Feb 9;24(1):179. doi: 10.1186/s12879-024-09055-z. PubMed 38336649 ↗
  • Ribeiro F, Schroder VE, Kruger R, Leist AK; CON-VINCE Consortium. The evolution and social determinants of mental health during the first wave of the COVID-19 outbreak in Luxembourg. Psychiatry Res. 2021 Sep;303:114090. doi: 10.1016/j.psychres.2021.114090. Epub 2021 Jun 30. PubMed 34247057 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 14, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04379297
Lead sponsor
Luxembourg Institute of Health
Collaborators
Luxembourg National Research Funds, University of Luxembourg, Centre Hospitalier du Luxembourg, TNS-Ilres, Laboratoires Réunis, BioneXt Lab, Ketterthill, Laboratoire National de santé
Responsible party
Sponsor
First posted
May 7, 2020
Start date
Apr 10, 2020
Primary completion
Jun 10, 2021
Completion
Sep 30, 2022
Last update
Aug 14, 2024

Study contacts

Rejko Krüger, Dr
principal investigator · Luxembourg Institute of Health

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.

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